College Course on DMD Available Online

A spring 2014 course from Ohio State University will emphasize Duchenne muscular dystrophy mechanisms, research, and clinical and social aspects

by Margaret Wahl on January 8, 2014 - 12:09pm

A course on Duchenne muscular dystrophy (DMD), geared toward graduate and upper-division undergraduate students and held at Ohio State University College of Medicine and Nationwide Children's Hospital in Columbus, is open to the public, without charge, via real-time streaming and podcasts.

The course, which starts Jan. 9, 2014, runs through April 17, and is taught on the Columbus campus every Thursday in Parks Hall from 2:30 to 3:30 p.m. Eastern time except for March 13, when no class will be held.

About the DMD course

The course will be overseen by Denis Guttridge and Jill Rafael-Fortney from the Ohio State University College of Medicine. Each lecture will be given by a different DMD or muscle disease expert or advocate.

The Feb. 13 class requires prior online viewing of Darius Goes West, a film about a 15-year-old with DMD who is leaving home for the first time.

Other classes will be devoted to skeletal muscle and its disorders through the perspective of DMD. Lecturers will explain the clinical aspects of this disease and research being pursued in the laboratory and clinic, as well as the basic structure, function and molecular mechanisms of skeletal muscles.

To view the course live or by podcast

Visit on your computer, tablet or smartphone to view the course live. Click the event with the corresponding date in the “Upcoming & Live Events” section. To view a past lecture, click the desired event in the “Archived Events” section. Select "Full" in the top right corner of the video to obtain a full screen. Questions also can be asked during a live lecture by typing in the comment box below the video. These will be answered by the lecturer if time permits.

Podcasts also will be posted and archived at Center for Muscle Health and Neuromuscular Disorders

Course Schedule

January 9
Clinical/genetics/diagnosis overview — Kevin Flanigan, M.D.
History of dystrophin gene cloning — Arthur Burghes, Ph.D.

January 16
Overview of skeletal and cardiac muscle physiology and measurements — Paul Janssen, Ph.D.

January 23
Histopathology/pathophysiology overview — Zarife Sahenk, M.D., Ph.D./Jill Rafael-Fortney, Ph.D.

January 30
Dystrophin glycoprotein complex discovery and associations — Rachelle Crosbie, Ph.D. (University of California, Los Angeles)

February 6
Cardiomyopathy — Subha Raman, M.D.

February 13
Discussion of Darius Goes West — Denis Guttridge, Ph.D. and Jill Rafael-Fortney, Ph.D.
"Darius Goes West" — out of class assignment
To watch film online, go to:

February 20
Summary of preclinical and transgenic models — Jill Rafael-Fortney, Ph.D.

February 27
Membrane damage and repair — Noah Weisleder, Ph.D.

March 6
Glycosylation and membrane stabilization — Paul Martin, Ph.D.

Spring Break (March 13)

March 20
Inflammation — Jim Tidball, Ph.D. (University of California, Los Angeles)

March 27
Signaling pathways — Denis Guttridge, Ph.D.

April 3
Fibrosis — Federica Montanaro, Ph.D.

April 10
Gene therapy, exon skipping, pre/neonatal testing — Jerry Mendell, M.D.

April 17
Perspective from a parent and advocate — Pat Furlong, Parent Project Muscular Dystrophy

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