The following story includes items about: Becker muscular dystrophy, centronuclear myopathy, type 1A Charcot-Marie-Tooth disease, congenital muscular dystrophy, Duchenne muscular dystrophy, limb-girdle muscular dystrophy, Miyoshi myopathy (distal muscular dystrophy), type 1 myotonic muscular dystrophy, myotubular myopathy, nemaline myopathy, and spinal muscular atrophy
The WNT7a protein increases proliferation of muscle repair cells, a finding that could have implications for MD treatment
In experiments in mice, Michael Rudnicki, an MDA grantee at the Sprott Center for Stem Cell Research at Ottawa Hospital Research Institute (OHRI), and colleagues, found the WNT7a protein stimulates muscle repair by causing proliferation (an increase in number) of "satellite stem cells." They say the protein probably operates similarly in humans. The findings were published June 5, 2009, in the...
Long before "stem cell" became a household term, people had observed that plants and animals can, within limits, repair damage they sustain.
Wounds heal, broken bones knit, and lost blood is replenished. Mowed grass soon regrows, and barren trees sprout new leaves in spring. Cut off a limb of a salamander or some other amphibians, and it regrows. But the limbs of other animals, once gone, can’t...
Michael Rudnicki, Ph.D.
AffiliationOttawa Health Research Institute(Canada)
StrategyDecoding pathways of muscle-cell development and repair