Each muscle fiber (mature muscle cell) is surrounded by a membrane (covering) that separates the inside of the fiber from the material outside the fiber. The material outside the fiber is called the extracellular matrix.
A change in the LTBP4 protein gene reduces muscle-damaging signals in mice with a disease resembling LGMD2C
New research has shown that a change in a gene not previously connected to type 2C limb-girdle muscular dystrophy (LGMD2C) modifies the severity of the disease in mice and is likely to do the same in people with this and perhaps with related types of muscular dystrophy.
Can sarcoglycan proteins help compensate for dystrophin's absence?
Delivering the gene for the missing dystrophin protein to the muscles of children and young men with Duchenne muscular dystrophy (DMD) is one of several therapeutic avenues under intense investigation in this disease. However, the strategy has technical drawbacks, and some experts worry that introduction of a previously absent protein could provoke a dangerous immune response.
This article includes items about clinical trials in: Duchenne MD, limb-girdle MD, distal muscular dystrophy, and acid maltase deficiency.