lamin A/C gene

Two already-approved drugs have been found to benefit cardiac function in mice with lamin A/C mutations, which underlie a form of EDMD and LGMD1B

posted on July 30, 2012 - 6:00am
Update (Sept. 10, 2012): Information about the potential for serious side effects with temsirolimus and rapamycin was added to this article.

An interview with MDA research grantee Howard Worman explores new ideas for treating the cardiac abnormalities associated with lamin A/C mutations

posted on May 30, 2012 - 2:15pm
Recently, MDA grantee Howard Worman at Columbia University, and colleagues, published encouraging results about the effects of a drug called selumetinib on the hearts of mice with a genetic mutation that's found in a form of Emery-Dreifuss muscular dystrophy (EDMD). 

The drug improved heart function and survival in mice with lamin A/C mutations, which cause lamin A/C-related Emery-Dreifuss MD and type 1B limb-girdle MD

posted on May 18, 2012 - 2:00pm
Update (June 1, 2012): This story was updated to include the availability of a podcast on this topic.
posted on April 1, 2009 - 12:26pm
QUEST Vol. 16, No. 2
Story includes research items about: Charcot-Marie-Tooth disease, congenital muscular dystrophy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy (EDMD), type 1 myotonic muscular dystrophy, and spinal muscular atrophy - including, type 3 SMA and spinal-bulbar muscular atrophy (SBMA, Kennedy disease).