Howard Worman

Two already-approved drugs have been found to benefit cardiac function in mice with lamin A/C mutations, which underlie a form of EDMD and LGMD1B

posted on July 30, 2012 - 6:00am
Update (Sept. 10, 2012): Information about the potential for serious side effects with temsirolimus and rapamycin was added to this article.

An interview with MDA research grantee Howard Worman explores new ideas for treating the cardiac abnormalities associated with lamin A/C mutations

posted on May 30, 2012 - 2:15pm
Recently, MDA grantee Howard Worman at Columbia University, and colleagues, published encouraging results about the effects of a drug called selumetinib on the hearts of mice with a genetic mutation that's found in a form of Emery-Dreifuss muscular dystrophy (EDMD). 

Lamin defects may disrupt nerve-muscle signals in Emery-Dreifuss MD

posted on January 28, 2009 - 6:16pm
Mutations in the lamin A/C gene on chromosome 1 and the emerin gene on the X chromosome both can cause Emery-Dreifuss muscular dystrophy (EDMD), but the precise mechanisms by which they do so are still being identified. Now, a multinational team has found that, in mice with an EDMD-like disease, lamin protein defects interfere with the way cell nuclei normally localize in skeletal-muscle fibers...