An interview with MDA research grantee Howard Worman explores new ideas for treating the cardiac abnormalities associated with lamin A/C mutations
posted on May 30, 2012 - 2:15pm
Recently, MDA grantee Howard Worman at Columbia University, and colleagues, published encouraging results about the effects of a drug called selumetinib on the hearts of mice with a genetic mutation that's found in a form of Emery-Dreifuss muscular dystrophy (EDMD).
Lamin defects may disrupt nerve-muscle signals in Emery-Dreifuss MD
posted on January 28, 2009 - 6:16pm
Mutations in the lamin A/C gene on chromosome 1 and the emerin gene on the X chromosome both can cause Emery-Dreifuss muscular dystrophy (EDMD), but the precise mechanisms by which they do so are still being identified.
Now, a multinational team has found that, in mice with an EDMD-like disease, lamin protein defects interfere with the way cell nuclei normally localize in skeletal-muscle fibers...