MDA-supported scientists in Ottawa have found that controlled damage to DNA is required before immature muscle cells can mature into muscle fibers.

posted on February 23, 2010 - 9:48am
Remodeling a building usually requires some degree of dismantling before new construction can begin. That principle, it now seems, also may apply to the remodeling of the body's cells.  Scientists at Ottawa Hospital Research Institute and the University of Ottawa have found recently that it applies to muscle cells, which can only develop from a stemlike state into mature muscle fibers after...

Studying the mechanisms controlling gene activity

posted on December 31, 2009 - 1:15am
QUEST Vol. 17, No. 1
Slip the word “genetics” into a casual conversation and you likely won’t get too many questioning looks. Most people basically understand that “genetics” refers to DNA and genes, the blueprint of life, the code that determines whether someone has blue eyes or green. Many are familiar, too, with the idea that “genetics” can cause a variety of health conditions: diabetes, breast cancer, muscular...

A report on drug development in neuromuscular diseases as of January 2009

posted on January 1, 2009 - 2:37pm
QUEST Vol. 16, No. 1
In the era of molecular biology, the drug development process has moved from a “let’s try it and see what happens” approach to a scientifically based process of discovery and application. For many of the diseases in MDA’s program, drug discovery begins with gene discovery — identifying a gene that, when flawed, causes a disease.

Genetic testing in the 21st century

posted on November 1, 2008 - 5:42pm
QUEST Vol. 15, No. 6
From the Human Genome Project to TV medical and crime shows, to an evergrowing list of genetic tests purported to diagnose diseases, trace your ancestry or predict your future, DNA seems to be the subject of the day. Even those who choose not to undergo testing find it hard to ignore. Whether or not to get tested is a personal decision. But since the DNA testing genie isn’t going back in the...
posted on March 1, 2005 - 10:55am
In this article: research news about prednisone in Duchenne MD; tests for Duchenne and Becker MDs; and the latest progress in research for spinal muscular atrophy