DMD research

Increasing levels of heat shock protein 72 reduced signs of Duchenne MD in mouse models of the disease

posted on April 12, 2012 - 9:28am
New research suggests that a potential strategy for treating Duchenne muscular dystrophy (DMD) may be to increase levels of heat shock proteins inside muscle fibers. Heat shock proteins exist naturally inside cells, where they assist in the folding and unfolding of other proteins. Their levels are increased when cells are exposed to various stresses, such as high temperatures.
posted on March 31, 2011 - 11:40am
QUEST Vol. 18, No. 2
Dongsheng Duan's interest in gene therapy to treat diseases goes back a long way, although his initial focus wasn't muscular dystrophy. "I came to the muscle field by accident," says Duan, an MDA research grantee and professor of molecular microbiology and immunology at the University of Missouri at Columbia. "It was not something I intended to do when I was young."
posted on October 1, 2010 - 2:25pm
QUEST Vol. 17, No. 4
Update (June 16, 2014): As of June 2014, the following seven centers comprise the MDA DMD Clinical Research Network: University of California, Davis; Nemours Children's Hospital, Orlando, Fla.;  Boston Children's Hospital; University of Minnesota Medical Center, Minneapolis; Washington University, St. Louis; Nationwide Children's Hospital, Columbus, Ohio; and Children's Medical Center of...
posted on October 1, 2010 - 12:25pm
QUEST Vol. 17, No. 4
Featured in this issue: First U.S. exon-skipping trial opens * Utah researchers seek families with Ullrich CMD or Bethlem myopathy * Acceleron receives Fast Track, Orphan Drug designations for ACE031 * BioMarin abandons BMN195 development
posted on November 1, 2005 - 9:53am
QUEST Vol. 12, No. 6
Emanuela Gussoni, Ph.D. AffiliationChildren’s Hospital and Harvard University, Boston StrategyIsolating side population cells from muscle tissue StatusLaboratory experiments