Are myelin and axons 'talking' to each other — and what are they saying?

posted on July 1, 2011 - 3:52pm
MDA-supported research in Charcot-Marie-Tooth disease is focused on figuring out what goes wrong at the molecular level in CMT-affected axons or the myelin sheaths that surround them, rather than on attempting to fix the problem directly or preserving nerve function in spite of it. A central theme emerging from the last decade of research is that myelin and axons require constant signals from...

A useful but unwieldy CMT classification system helps make sense of the many subtypes of the disease

posted on July 1, 2011 - 2:17pm
QUEST Vol. 18, No. 3
As recently as the early 1990s, many experts hoped that understanding just a few genes that influenced the development or maintenance of myelin or axons would explain all of Charcot-Marie-Tooth disease. It didn’t turn out to be that simple, however. Today, there are dozens of genes recognized that, when flawed, can cause CMT.