MDA-supported researchers have developed a mouse with a mutation in a muscle sodium channel and a disease that mimics human hypokalemic PP
MDA grantee Stephen Cannon at the University of Texas Southwestern Medical Center in Dallas coordinated a study team that has developed a mouse model of one type of hypokalemic periodic paralysis, publishing the development in the Oct. 3, 2011, issue of the Journal of Clinical Investigation.
You can read the full paper online without charge at A sodium channel knockin mutant (Nav1.4-Rgg9H) mouse model of hypokalemic periodic paralysis.
Hypokalemic periodic paralysis, a genetic muscle disorder involving attacks of weakness or paralysis associated with low serum potassium levels, can be caused by any of several different mutations in the genes encoding a muscle calcium channel or sodium channel. The newly developed mouse model has a mutation in the muscle sodium channnel.
The mouse model will enable researchers to study the sodium-channel form of hypokalemic periodic paralysis in more depth and test potential treatments.
For more about periodic paralysis, see In Focus: Periodic Paralysis, a report on disease management and research, Quest, July 2009.