New Tadalafil Trial in Becker MD Now Open

Researchers invite men with Becker MD (ages 15-50) who meet study criteria to participate in a trial to determine whether tadalafil can improve exercise tolerance

Article Highlights:
  • Previous research has shown that the blood-vessel dilating drug tadalafil (Cialis) can normalize blood flow to muscles in men with Becker muscular dystrophy.
  • A new trial will test whether this normalization of blood flow results in improved exercise tolerance.
  • The study requires two visits to Los Angeles, each lasting three days.
by Margaret Wahl on October 7, 2013 - 5:00am

A new trial of tadalafil (Cialis), a drug that dilates blood vessels, is now under way at Cedars-Sinai Medical Center in Los Angeles for men with Becker muscular dystrophy (BMD) who meet study criteria.

The new study is an outgrowth of previous research on tadalafil in BMD, which showed that there is a blood flow abnormality in men with the disease and that a single oral dose of tadalafil reverses this abnormality.

"We now wish to extend these exciting research findings to see if tadalafil can also improve exercise tolerance — allowing patients with BMD to exercise longer without [overly] stressing the working muscles," said Ronald Victor, a cardiovascular disease specialist and the principal investigator for the new trial.

About the tadalafil study

The study involves two visits to Cedars-Sinai, separated by at least one week, and each consisting of three study days. For example, participants can arrive on a Sunday and leave on a Wednesday. There is no cost to participants, and Cedars-Sinai will cover travel and lodging expenses, as well as $150 per study day ($900 total).

Prospective participants must:

  • be male;
  • be 15-50 years old;
  • have a diagnosis of Becker muscular dystrophy made by a clinical neurologist and based on muscle biopsy analysis or DNA analysis; and
  • be able to walk 200 meters (656 feet) unassisted in six minutes.

Prospective participants must not:

  • have heart or lung disease by history or physical exam;
  • have a history of high blood pressure (blood pressure greater than 140/90);
  • have a cardiac ejection fraction (a heart function measurement) of less than 50 percent; or
  • have diabetes mellitus.

To participate

Contact Xiu Tang at xiu.tang@cshs.org or (310) 967-0697, or Michael Nelson at michael.nelson@cshs.org or (310) 967-3844. Both are located at Cedars-Sinai in Los Angeles.

For more information

To learn more about blood flow and muscular dystrophy, see Enhancing Blood Flow to Exercising Muscles.

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