Drisapersen Appears Safe in Non-Walking Boys with DMD

Safety and blood levels of GSK's exon-skipping drug were evaluated in boys with Duchenne MD who were no longer walking and had specific dystrophin mutations

Article Highlights:
  • Drisapersen, designed to target exon 51 of the dystrophin gene in boys with Duchenne muscular who have certain dystrophin mutations, reached blood levels approximately proportional to the injected dose after a single injection at two of the three dosage levels tested.
  • There were no serious adverse events reported, although there were non-serious adverse events.
by Margaret Wahl on November 2, 2012 - 5:15pm

-A +A

The multinational pharmaceutical company GlaxoSmithKline (GSK) has announced promising results for its phase 1 trial of the exon-skipping drug drisapersen in boys with Duchenne muscular dystrophy (DMD) who are no longer walking.

The phase 1 trial was designed to test safety, tolerability and pharmacokinetics (what the body does to the drug) of drisapersen, not to test drug efficacy.

Results showed that drisapersen (formerly GSK2402968) reached blood levels roughly proportional to the injected dose at two of the three dosage levels tested and that adverse events were not serious.

This trial opened in June 2010 at two sites — Columbus, Ohio, and Paris, France. It included 20 boys with DMD who:

  • had specific mutations in the dystrophin gene amenable to treatment by skipping the exon 51 section of this gene; and
  • had been using a wheelchair full time for at least one year but not more than four years.

Trial participants were randomly assigned to receive either a single injection of drisapersen at varying dosage levels or a placebo injection.

GSK announced detailed results of this phase 1 trial on its website at Result Summaries: GSK2402968 on Nov. 2, 2012.

Blood levels, adverse events analyzed

In summary, the investigators found that:

  • When drisapersen was injected at a dosage level of 3 or 6 milligrams per kilogram of body weight, blood levels of the drug appeared to be approximately proportional to the dosage given. However, when the results for the 9-milligram-per-kilogram group were included, blood levels did not increase proportionally.
  • In the 3-milligram dosage group, all six participants who received drisapersen injections reported non-serious adverse events, with the most frequently reported being injection site discoloration and injection site induration (tissue hardening).
  • In the 6-milligram group, all six participants who received drisapersen injections likewise reported non-serious adverse events, with the most frequently reported being injection site discoloration and injection site induration.
  • In the 9-milligram group, all three people receiving drisapersen injections reported non-serious adverse events, with the most frequently reported being injection site discoloration, injection site inflammation and fever.
  • Two of the five participants who received placebo injections reported non-serious adverse events, with the most frequently reported being injection site discoloration and injection site induration.
  • There were no serious adverse events or fatalities.
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Charlie Seen: The Playboy

Charlie Seen: The Playboy Interview “I’m not crazy anymore,” Charlie Sheen announced this past January at the Fox Network Television Critics Association party in Pasadena, California. He said it with a chuckle, but there was an unmistakable sincerity to his confession. Usually when famous actors suffer a public scandal there are apologies and pleas for forgiveness. Not too often do they come right out and admit they went bat-shit crazy.Of course, denying his insanity might have been an exercise in futility. Few celebrities have had quite as dramatic or memorable a meltdown as Charlie Sheen. When 2011 began he was one of the highest-paid actors on TV, earning an estimated $40 million annually for starring on Two and a Half Men. And then, seemingly overnight, he went off the rails. The show took a production hiatus in late January as Sheen dealt with his public addictions to drugs, porn stars, trashing hotel rooms, etc., and during the next few months he went on a media tirade, doing increasingly erratic TV and radio interviews. He coined such catchphrases as “winning,” “tiger blood” and “Adonis DNA.” He claimed to be a warlock and a Vatican assassin who was fed up with “pretending I’m not a total bitchin’ rock star from Mars.” One minute he bragged about “banging seven-gram rocks” during a typical night of partying, and the next minute the only drug he’d admit to using was called Charlie Sheen, which he claimed normal people couldn’t take without melting their faces and causing their children to weep over their exploded bodies. He introduced the world to his “goddesses,” two girlfriends (one, Bree Olson, is a former porn star) who lived and had sex with him at his self-described Sober Valley Lodge. In March Sheen was fired by Warner Bros. for “felony offenses involving moral turpitude,” which at the time seemed to be an understatement. It took more than a year, but Sheen is finally back on TV with a new comedy, Anger Management, on the FX network. He plays a minor league baseball player turned therapist, and it will be either a triumphant return for the troubled actor or the final nail in his acting career’s coffin. We sent writer Eric -Spitznagel, who recently interviewed Jon Hamm and Craig Ferguson for -playboy, to meet with Sheen and find out whether the former tiger-blood-fueled warlock is really on the road to recovery. He reports: “After rehearsal for Anger Management wrapped, Sheen and I talked in his trailer, the infamous former party bus he’s had since Spin City, online coach factory outlet which is now decorated with crayon drawings from his children and outfitted with a fridge weirdly lacking in alcoholic beverages.“The next day, he invited me to his home in a Los Angeles gated community, just down the street from rock guitarist Slash. Once again the setting was more domestic than debauched. There was an actual apple pie cooling on the stove. ‘It’s all set dressing,’ Sheen joked. ‘As soon as you leave, all the drug paraphernalia and porn stars come out of the attic.’ Sheen made me a smoothie, spiked with nothing but strawberries. After he showed me his dad’s helmet from Apocalypse Now and we’d talked at length about baseball and why the Chicago Cubs will probably never win another World Series, we sat at his kitchen table and got down to business. During our conversation Sheen smoked so many -Marlboro Reds that even my lungs hurt.”PLAYBOY: Anger Management is the second time you play a character named Charlie, after Two and a Half Men, right?SHEEN: The third. I was Charlie on Spin City too. PLAYBOY: Is that by choice? Is it just easier for you to remember?SHEEN: I think it happens a lot in sitcoms. Jerry Seinfeld, Ray Romano and Bob Newhart all used their real first names. It’s also easier for audiences so they’re not confused by a new character. They feel they’re already familiar with me right off the bat.PLAYBOY: The Charlie you played on Two and a Half Men had a lot in common with you. How is the Anger Management -Charlie similar to you?SHEEN: He’s not. I hear that shit all the time. It’s like, Really, you want me to put my life on TV? Put it on fucking cable on Mars. “But it’s so similar!” Really? Have you ever hung out with me? Idiots.PLAYBOY: So you never draw on your personal life for your fictional life?SHEEN: Now and again there are themes that might be similar. I think that’s fine. If it’s done tastefully, it’s cool. There are times when they go too far and I’ll tell them. I’m done playing a drunken, womanizing, immature character. This time I’m playing an adult. The guy on Anger Management is professionally accomplished, a former ballplayer learning to overcome his anger issues.PLAYBOY: You went to anger therapy, right?SHEEN: I went for a year. I learned some good shit there. This may sound stupid, but it all comes down to sticks and stones. You know what I mean? Sticks and stones may break my bones——PLAYBOY: But words will never hurt me.SHEEN: Exactly. There’s so much value in that. The idea of leaving the room sometimes when you’re angry. Just leave the room! If someone follows you, go to a different room. If they keep following you, get in your car. If they follow you in your car, drive to a police station. There are ways to not engage. It’s like my dad Martin Sheen] always said: Women know what buttons to push because they helped build the machine. So every time you give in to that, you’re playing right into their hands. It’s a good point. He’s a wise man.PLAYBOY: Your dad just celebrated a big anniversary.SHEEN: His 50th wedding anniversary.PLAYBOY: How does somebody get to 50 years in a marriage?SHEEN: I have no fucking idea. PLAYBOY: Has he given you any relationship advice?SHEEN: Dad always stressed the value of the truth. He said you never have to look over your shoulder when you tell the truth. You never have to remember the details, because they are what they are. And you don’t have to make sure your story matches everyone else’s. Just tell the truth and you’re home free. If there are amends to be made, you make them. You own it and move on.PLAYBOY: Speaking of telling the truth, we should talk about last year and your whole so-called meltdown.SHEEN: Where do you want to begin?PLAYBOY: Let’s start with the basics. What the hell happened?SHEEN: I don’t know what happened. I think I cracked.PLAYBOY: Did Two and a Half Men break your brain?SHEEN: I don’t think it was the show in particular. It was the buildup of all the time I’ve been in the business, the divorces and everything. I started to unravel. I was mad about having to play the game—not that I was playing it well, but I’d been doing it for so long. I finally just said the things I had always been thinking. But in the middle of a psychotic break.PLAYBOY: Sean Penn called you a performance artist. Is it possible the whole year was one big hoax?SHEEN: That’s cool that he said that. It’s a compliment, but it’s not what was going on. I didn’t have a master plan. I didn’t realize it was going to create such a global firestorm. At the time, it felt like I was watching a lot of it from above, you know what I mean?PLAYBOY: Like an out-of-body -experience?SHEEN: Yeah. It was surreal. And it never occurred to me where this stuff was going to end up or how it was going to be perceived. I didn’t care about anything beyond the moment. And then I was a little shocked by how huge the whole thing became. It was like an organism you couldn’t stop. It kept growing.PLAYBOY: Some of the things you said will haunt you forever. “Winning” is now part of the pop-culture lexicon.SHEEN: I guess so. You know what’s interesting about that? It’s stated in the present tense. We were in the act of winning. It was current. It wasn’t “We’ve won” or “We’re going to win.”PLAYBOY: It was an coach backpacks active verb.SHEEN: Exactly. PLAYBOY: Is that why people connected with it so much?SHEEN: That’s part of it. The economy was in the toilet and people were dealing with their horrible bosses. So they were like, “Oh, here’s a guy who stood up to his boss, who had the balls to say, ‘Fuck it, you’re wrong, I’m right.’?”PLAYBOY: You kept insisting you were winning when everything that was happening in your life and career at the time seemed like the complete opposite of winning.SHEEN: Absolutely. I was in total denial. PLAYBOY: Was it just positive thinking? If you say you’re winning enough times, maybe things will turn around?SHEEN: It wasn’t that bleak in my head. I felt I was winning by finally being able to speak my mind. I felt that was some sort of victory. And then it was fueled by the insane public outpouring of support.PLAYBOY: Not only were you winning, but you called yourself a warlock.SHEEN: I didn’t know what the hell a warlock was; I just liked the way it sounded. It’s got war in it; it’s got a kah sound. War-lock. Remember the Salem warlock society? They were going to cast a hex on me.PLAYBOY: Because you were making a mockery of their religion?SHEEN: Something like that. I was hurting the warlock name. I was like, “Bring it on! I’ll eat your hex for breakfast.” It’s so fucking stupid. I’m in a beef coach backpacks with a warlock society? You’re kidding me, right? How do you go from making Oliver Stone movies to being in a feud with warlocks?PLAYBOY: The list goes on and on. Tiger blood, Adonis DNA, you’re on a drug called Charlie Sheen.SHEEN: Most of it came out of nowhere. It wasn’t planned, it was just random. The tiger blood? I don’t know. It’s just a very dangerous animal. And there’s a tiger in Apocalypse Now, by the way, so maybe there’s a connection there. Adonis DNA? I cheap coach backpacks don’t know what the fuck that was about. That was just stupid. That went a http://www.ccoachfactoryoutlets.com/ little far.PLAYBOY: You made a lot of allusions to war during that period, especially when talking about Two and a Half Men creator Chuck Lorre and CBS. Did it feel as though you were in a literal war?SHEEN: It felt like combat, yeah. I don’t know what real combat feels like, but it felt like emotional combat, like spiritual combat. One thing I can’t tolerate is being disrespected. Fuck that. I’m talking about literal, genuine examples of coach factory disrespect, where you feel unappreciated. Guys want to be respected and acknowledged. They want to feel what they contributed matters. I felt I contributed a lot, and suddenly it didn’t matter.PLAYBOY: Why would CBS and Lorre change their minds about you?SHEEN: Because they read things about me and believed them. They were like, “He’s crazy” or “He’s drunk” or “He’s fucked-up” or “He’s a fucking weirdo” or whatever. But if you’re special, you’re tortured. I know that sounds arrogant, but you can’t not be special and have a 30-year career. You can’t not be a little different from others and be successful for three decades. Your mind has to work a little differently than the average brain. But here’s the good news. I’m not there anymore. I’m not working with CBS or Warner Bros. or Chuck anymore. Good news for them and good news for me.PLAYBOY: Did you ever enjoy yourself on Two and a Half Men?SHEEN: The early stuff was fun. It was fresh, and we were still kind of finding our way. The first time and a Half Men co-star] Jon Cryer and I read together, it was magic. No question.PLAYBOY: How is your relationship with Jon these days?SHEEN: I don’t have one.PLAYBOY: You said some cruel things about him last year. You called him a troll and a traitor. Was that the heat of the moment, or did you really feel that way?SHEEN: That was wrong. I whaled on him unnecessarily.PLAYBOY: But at the time did you feel he should have defended you?SHEEN: I made a mistake. But yes, I felt he should have come forward with some kind of support. But says who? What rule book is that written in? It’s not. He was trying to keep the shit together, trying to cover my ass, pick up the slack. He just got caught in the crossfire. He’s a beautiful man and a fucking fabulous dude and I miss him. I need to repair that relationship, and I will. I will reach out and do whatever is necessary.PLAYBOY: Looking back on it a year later, do you have a better understanding of what went wrong, why you lost Two and a Half Men?SHEEN: I know exactly what went wrong. CBS and Warner Bros. were in breach. That’s it. That’s why this thing never went to any kind of arbitration. They knew they’d have to admit they screwed up. They were too involved in their own egos and their own emotions. I guess that’s why I went full-court press on them, because I knew they didn’t have a case. My job was to show up and act; their job was to write. Or it was someone’s job to write, and Chuck Lorre decided he wasn’t going to do it anymore.PLAYBOY: They would probably claim it had more to do with your drug problems.SHEEN: That was a fucking hernia, by the way.PLAYBOY: What was?SHEEN: In January, before I got fired, when I went to the hospital. The hernia was real. Everybody thought I had OD’d or whatever. No, I had a fucking hernia blow out of my stomach. I called the paramedics, because that’s what you do, right?PLAYBOY: There were tabloid reports that you had a suitcase of cocaine delivered to your house.SHEEN: That’s such bullshit. And that’s what I got fired over. I didn’t get fired for the Plaza Hotel thing he was accused of assaulting a porn star]; I didn’t get fired for the Vegas bender. I got fired for a hernia. And it’s real. Check it out. up shirt] See that? out stomach and points to hernia scar] It’s there. I didn’t get it fixed because I thought we were going to court and I would have to show this from the stand.PLAYBOY: There were rumors that the hernia happened after several days of constant partying and drugs.SHEEN: No, that’s just not true. It was because of a Dave Chappelle sketch.PLAYBOY: Oh, come on.SHEEN: Remember that scene where he’s a blind white supremacist who doesn’t know he’s black? Have you seen it? It’s the funniest thing in the world. He becomes a Klansman, and he’s railing against black people. It’s insanely brilliant. 123Next
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How the innovation in the MLB

How the innovation in the MLB might mean moving backwards I’m sitting in what a city-slicker might call the back 40, the 500-level seats, complete with the broad iron brandishing of steel girders supporting a roof that retracts, opening on occasion to release all the trapped echoes held within this monstrous dome. I can literally touch the walls of this cold alien world and look out upon its neon green ecosystem, a replica field with little tiny players playing a little tiny game. The air up here is different: it’s more dense, noxious, cycled through a complicated series of fans and filters and released back into our lungs. The sounds are softer, dulled by all the dead air. Up in the far reaches of the Rogers Centre there is no telling sound to signal the discord of a hit in a once-perfect game: that cacophony is lost. The alarming crack of a bat, the slap of leather on leather, even the once-raucous roars of the crowd circa the early nineties (alive again, I must say) are reduced to little more than a dull thud in this cordoned-off, covered and cavernous space. You’re removed; all the tight-knit, anxiety-inducing, close-quartered encounters that make a ballpark infuriating and at the same time alive and intimate are gone. Amid the dead gray of a concrete mass and the cracking, chipped blue walls of the once-infamous SkyDome, a game that is usually so personal, so close and so real seems less so. Somehow it seems less alive. Less human.Back in the late ’70s and all through the ’80s, baseball stole out from under the summer skies and moved indoors. The reason was twofold: it was a game repeatedly subject to whims of weather and being supplanted in cities with hostile climates, cities like Seattle and Tampa Bay that simply couldn’t support a team whose games always had a 50/50 chance of being rained out. In places like Montreal, Minnesota and Toronto, moving indoors made sense if the teams were ever to play in October, when precipitation more often than not meant snow. It just made sense. We’d learned long ago how to weather a storm; so too, we figured, should our national pastime.The second reason for the retreat was financial: moving into monstrous stadiums, stadiums already in place or at least in the planning stages, made sense if multiple teams could play in them and in turn cut the cost. Having the Seahawks, the SuperSonics and the Mariners all sharing space in the Kingdome meant year-round revenue at a third of the cost it would take to build three separate venues. Again, it just made sense. But what a financial or weather report could never factor in, what it had no graph for, was the impact moving into these hulking monstrosities would have on the game. For football, it was fine; you could fill the stadium and no one was any the wiser. Ditto basketball, whose fans were born and bred in the rafters, already used to the game being coach backpacks played indoors. But for baseball, a slower game attended in equal parts for the sport and the experience, the Kingdome, the Hubert Coach Outlet Online Humphrey Metrodome, SkyDome and Tropicana Field were cold, dead places, places that lacked intimacy or a feel for the game, Frankenstein’s monsters born to resemble a baseball field but whose dimensions were skewed and cold to the touch. These stadiums, however practical on paper, just couldn’t complement the experience; they complicated it.And so fans revolted: to this day the four parks mentioned above, some no longer standing, still rank among the worst venues to watch a baseball game. They sucked the sunlight and soul from the seats. There was nothing appealing about wasting away an afternoon on a concrete slab under an overly fake fluorescent sun. Today, only three parks remain that can be described, architecturally, as “multipurpose”: the Rogers Centre, the Trop and the ungodly eyesore of the Oakland-Alameda County Coliseum. The rest, primarily built, rebuilt or renovated in the ’90s or early 2000s in a movement we’ll call reactionary, a return to whatever it was we found in the sun, are best described as “retro classic,” “retro modern” or “retro modern classic.” That, of course, is not to say that they’re all ideal (or that we care to distinguish between “retro classic” and “retro classic modern”); Busch Stadium is still an expansive football-fieldesque chasm, Chase Field is more akin to the basement pit in Silence of the Lambs and the new Marlins Park in Miami is a contemporary spastic circus of poor sightlines and scenery. But they are all more alive. They are more in tune with the game, closer to recapturing the experience of the ballpark, of breathing life, literal un-cycled air back coach backpacks into the afternoon.And yet after almost two decades of staring at dead space, we find ourselves on the precipice of another monster threatening the humanity of a game we just took back from the cold clutches of modernity, rescued from the dehumanizing qualities of a crass, concrete world. Here we are welcoming the possibility of instant replay, of a strictly defined strike zone upheld by an army of robotic umpires with laser-like accuracy and not an ounce of give. Ominous, always-right overlords without a drop of humanity.Prompting this discussion is a recent strange series of blown calls: an obvious safe call botched by Tim Welke, back-to-back balls called strikes by Bill Miller, last year’s 19-inning mess at home in Atlanta and of course Armando Galarraga’s and R. A. Dickey’s not-so-perfect games.But as infuriating as a blown call might be, as important as a two-out, 3-2 bases loaded ball that should have been a strike might be to the pitcher, the human element remains as much an integral part of baseball as the bat or the ball or the park. It’s what keeps us coming back; it’s what drives fans to fury. It does occasionally backfire, at times it is grossly unfair, but it is what keeps the fans connected to the play on the field. In the same way that the colossal stadiums of yesteryear moved us both figuratively and literally further away from the game, the introduction of what will undoubtedly be overused replay or worse, the reduction of the strike zone to systematic science, threatens the very lifeblood of the game.Long gone would be the days of Lou Piniella waddling in a huff to home plate. No more ejections or irrational implosions on the mound by a pitcher still fuming over an inside corner that was actually a ball. No more arguments coach backpacks between friends at the bar over high strikes and slow looping curves. No more questioning safe at second, out at third or dead to rights at home. It would all boil down to a science, a little red blip, a flashing little battery-controlled robot that’s always right but in the end would be profoundly wrong. This is the argument of purists. The argument for the presence of human error in a game of measured skill can only be a purist one in the sense that the game remains as close to its roots as possible, not that it is free from error. It comes from the mouths of the same people who found it uncomfortable, disconcerting to watch baseball in a dome under the ever-present and unnatural glow of fluorescent bulbs. From the people who gather around the water cooler at work to talk baseball, to dissect last night’s game down to the last pitch. For them, baseball, with all its blown calls, its crumbling but storied walls, its retro modern feel free from whatever architectural flight of fancy might be the choix du jour, baseball, with Coach Outlet all its imperfections, is perfect.
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20Q CHRIS HARDWICK

20Q CHRIS HARDWICK Q1PLAYBOY: Your podcast, called Nerdist, gets 4 million downloads every month. Are podcasts the future of comedy or just something to do while you wait to get cast in a sitcom?HARDWICK: I do podcasts for the same reasons I do stand-up comedy. I love it, and I don’t care if anybody else gets it. I don’t know if the podcast as a medium will ever have the cultural impact that TV and movies do. It may never be super-mainstream. For some people, you say podcasts and they’re like, “What the hell is that?” They don’t understand it’s like a radio show you can download. Mainstream culture is like your mom: It’s always a little late to catch on and gets easily confused by technology, but it means well.Q2PLAYBOY: What exactly is a nerdist? Is it just a fancy word for nerd? HARDWICK: I think the Urban Dictionary defines nerdist as “an artful nerd.” That’s not bad. It’s on the safe side of pretentious. Nerdists, unlike nerds, tend to be creators as much as consumers. They’re creative consumers. They don’t just sit and watch passively. They’re crafty. They make shirts and posters and confectionery things.Q3PLAYBOY: Nerds have been around since the dawn of time. Why are they getting respect now?HARDWICK: Because nerds make money. I hate to say it, but because of humanity’s capitalistic nature, money is important. And with money comes power. I think it’s also about accessibility. So many people of this current generation have grown up with technology and video games, it’s not nerdy to like that kind of stuff anymore. Nerd culture is ubiquitous.Q4PLAYBOY: Nerdist Industries is the name of your media empire of websites, podcasts and YouTube videos. In what ways are you similar to ruthless 19th century industrialist George Pullman?HARDWICK: In every way. I’ve always had a fondness for that satirical, Terry Gilliam–esque evil corporate megastructure, the kind of business that hangs banners that say making your life better as it throws kittens into the gears. I want Nerdist Industries to be like that. For a while we were using the slogan “Nerdist: Making Today the Yesterday of Tomorrow,” which is just stupid. It’s dumb doublespeak. But the whole idea of being an industry is about making fun of people’s confusion.Q5PLAYBOY: You were born in Kentucky and raised in Tennessee, but you don’t have even a trace of a Southern accent. Do you consider yourself a Southerner?HARDWICK: I love the South. Although I grew up primarily in Memphis, my family moved around a ton when I was a kid. I guess I never stayed in one place long enough to pick up the accent, but I definitely identify as a Southerner. I fucking love grits, for one thing. I am a grits-eating motherfucker. I love all Southern cooking—collard greens, black-eyed peas, I’ll eat it all. Put me in the kitchen and you’ll see how Southern I can be.Q6PLAYBOY: Your father is a retired professional bowler. Were you ever pressured to go into the family business?HARDWICK: Absolutely not. Both my parents recognized early on that I wanted to do something in comedy, and they were really supportive. They’re the ones who bought me Steve Martin records and let me watch R-rated comedies long before they probably should have. But I still spent a lot of time bowling as a kid, mostly because I grew up in bowling alleys. They were kind of my playgrounds. Not only was my dad a pro bowler, but my mother’s father and brother both owned their own bowling centers. I still bowl today, though I wouldn’t recommend doing it with me. I’m not fun to bowl with, believe me. I take it way too seriously.Q7PLAYBOY: How did you discover your nerd tendencies growing up in a bowling alley? It’s not a nerd-friendly environment.HARDWICK: It can be. That’s where I got into arcade games. My grandfather, my mom’s dad, who was a really smart and wonderful man, was a technophile. He was the first guy to buy those big laser-disc players in 1979. He had the latest camcorders and stereo systems and Betamax players. He noticed early on that video games were a big deal, so he set up a massive arcade in his bowling center in Florida. I spent all my time there. When I wasn’t playing video games, my friends and I would play Dungeons & Dragons or chess at the bar. I had full access to all my nerd obsessions. I guess when I think about it, I was a spoiled piece of shit.Q8PLAYBOY: You’re not a fan of competitive athletic sports. As a spectator or a participant?HARDWICK: Neither. I don’t think there’s anything inherently wrong with sports; I just don’t give a shit. When I see dudes in sports bars shoving chicken wings in their faces, watching a game and saying, “That’s my team,” it mystifies me. I’m like, You’re sitting on your fat ass. What are you doing that makes you a contributing member of the organization? You’ve lifted nothing but drumsticks for the past three hours.Q9PLAYBOY: Have you considered joining a fantasy league? They have statistics and math, all the nerd staples.HARDWICK: Yeah, that’s not a bad idea. I would have to look at it like a chess game, as a strategy. If I did that, I could probably find a way in. It would make my life a lot easier if I could find a way to appreciate sports. I mean, I’ve never watched an entire football game. It’s horrifying. So many dudes try to bond with me over sports. They’ll come up to me and say, “Hey, do you know the score of the game?” I won’t even know what to say. Game? What game? I can give you some quotes from the last Harry Potter movie. Does that help?Q10PLAYBOY: You majored in philosophy at UCLA. Were you just not interested in making money or having a career?HARDWICK: Steve Martin, my comedy idol, was a philosophy major in college. He once said that philosophy is a great thing for comedians to study because it screws up your thinking just enough. If you’re going into stand-up, you’re hyper-analyzing the world and asking as many questions about a thing as you possibly can so you can figure out the ultimate nature of that thing. If you want to get into comedy, it’s really the only subject worth studying.Q11PLAYBOY: Your first big career break was as a co-host with Jenny McCarthy on the MTV dating show Singled Out. Which leads to the obvious question——HARDWICK: No, I did not fuck Jenny McCarthy.Q12PLAYBOY: Actually, that’s not what we were going to ask, but thanks for clearing that up. We were wondering if hosting the show taught you any big life lessons about dating.HARDWICK: For me, the lessons of Singled Out weren’t about dating. They were about fame. I learned that just being on MTV doesn’t make you famous. When I got the job, I was like, Oh man, I’m going to be on a private jet with fucking Kurt Cobain. We’ll be toasting martinis and getting blown by mermaids. And of course none of that happened. The show ended, and I became an out-of-work comic with a drinking problem.Q13PLAYBOY: Is it true that Jon Stewart mocked you into sobriety?HARDWICK: In a way. I was in my apartment, watching The Daily Show, and McCarthy was a guest. Stewart made a joke about me. Somehow my name came up, and Stewart was like, “He gets our coffee now.” It devastated me. It was the first moment I took a long hard look at my life and my career. It made me realize, Oh my God, I’ve become that MTV stereotype I always worried about becoming. I was proud of Jenny, and I say that with no bitterness. There are only a handful of people who started their careers on MTV who managed to keep it going. There’s Jenny and Pauly Shore and maybe a few others. But it never happened for me. I became the washed-up drunk loser with floppy hair who used to be on a dating show.Q14PLAYBOY: How did you dig yourself out of that hole?HARDWICK: When I look back, every time I felt something bleak was happening with my career, I would make some sort of survival-based choice, doing something I could control. I was very lazy about doing stand-up when I was hosting Singled Out. I was like, “Whatever, I have a job.” But when I had nothing, it was a lifeline. It made me feel coach factory outlet I was finally taking control of my career. The same thing with the podcast. Every time I was rejected by the entertainment business, which was a lot, I’d be like, “Well, fuck you. herve leger dresses I’m going to do my own thing.” Even if nothing happened with it, it was my thing and they couldn’t touch it. Of course, the business didn’t give a shit at the time, but I was still muttering under my breath like a crazy person.Q15PLAYBOY: You wrote a self-help book called The Nerdist Way: How to Reach the Next Level (in Real Life). Are you better at giving advice or taking it?HARDWICK: It’s so much easier to give advice than to take it. But I tend to trust any advice that comes from years of fuck-up research. When I was younger, my parents used to say, “Trust us on this. We have more experience than you.” And I was like, “Shut up, you don’t know anything!” But I was an idiot. They did know more stuff because they’d experienced more things. They’d fucked up more often than I had. There’s no better path to knowledge than fucking up. coach factory outlet Q16PLAYBOY: You were part of a regular Dungeons & Dragons game with comedians Brian Posehn, Patton Oswalt and others. Why are comics drawn to fantasy role-playing games?HARDWICK: I really don’t know. Maybe because D&D is the perfect mental exercise. It’s math and fantasy. It’s statistics and Lord of the Rings. It requires you to use your mind but also be social. Our game was amazing just because everyone involved was so goddamn funny. Patton had a drunken dwarf character called Stump Hammer. I was a lawful good wizard named Blaividane, sort of an anagram of David Blaine’s name. Brian had a ninja character who was obsessed with pickles. It was some of the best times I’ve ever had playing D&D. I really miss it.Q17PLAYBOY: You don’t play anymore?HARDWICK: The bummer thing about a D&D game is that it’s like having a band. If one coach factory outlet person can’t show up, then the whole thing falls apart. Our game ended because our dungeon master got a girlfriend, and she didn’t want him playing D&D on Sundays with a bunch of guys for five hours. We’d run into him later, and it was always awkward. It was like we were a dude and he was our ex-girlfriend.Q18PLAYBOY: You’re a regular at Comic-Con in San Diego. Are we correct in thinking it’s like Plato’s Retreat with Spock ears? HARDWICK: There is an element of that, yeah. Hey, nerds made porn available on the internet—what else do you need to know? But that’s the vibe at comic book conventions in general. When I was growing up, nerds had this reputation for being virgins who lived in their parents’ basements. That’s certainly not the case now. I would say that nerds, as a rule, are much more sexually active than the average person. There’s a lot of anxiety and stress in the nerd brain, so sex is good for that.Q19PLAYBOY: You’re a Star Wars fanatic. Isn’t your girlfriend, Chloe Dykstra, part of Star Wars royalty?HARDWICK: In a way, yeah. Her dad did the effects for Star Wars. He helped develop the technology for the lightsaber. The freaking lightsaber! I’m not saying that’s why I go out with her, but it’s definitely a big check in the “pro” box. A couple of months herve leger dresses ago she brought me this gift bag, and she was like, “Yeah, I was just rifling around my dad’s garage.” It was an original Star Wars crew T-shirt, with a design I’d never seen before, and an original Star Trek: The Motion Picture crew shirt. It was the best gift I’ve ever gotten. I went on a tour of Skywalker Ranch a couple of years ago and saw the original everything—the original droids, the original concept art, the original lightsabers. I saw the original Yoda, and I’ll be honest, I wanted to spoon with him.Q20PLAYBOY: As a card-carrying nerd, this is probably the most important question you’ll ever be asked. If and when you have kids, how will you introduce them to the Star Wars movies? In what order?HARDWICK: You’re not kidding about it being an important question. I talk about this a lot. It’s a big moral quandary. Do you want your kids to experience it like you experienced it, or do you go in the proper order? I’ve heard arguments on both sides. The problem with doing it in numerical order is that it ruins the Vader “You are my father” surprise. The most convincing case I’ve read was by herve leger dress this guy Rod Hilton, who came up with something called the Machete Order. He recommends showing them like this: A New Hope, then Empire, then Attack of the Clones, then Revenge of the Sith, then Return of the Jedi, completely leaving out Phantom Menace. His point is Phantom is unnecessary, and parts two and three play like a flashback. It makes sense, but I still don’t know. I saw Star Wars in the theater with my dad, so if I had a kid, I’d maybe want to show the movies to him or her in that order, just for the tradition of it. I don’t know. This is too much pressure. It’s like asking where I want to be buried. Can I get back to you?
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Celebrity Interview with The

Celebrity Interview with The Big Bang Theory's Melissa Rauch Unless you’ve been living on another planet for the past six years, you or someone you know is likely glued to their television sets each week as the greater cosmos is explained by the quirky nerds of CBS’s The Big Bang Theory.When audiences aren’t scratching their heads trying to make sense of the asexual Sheldon Cooper’s way of life, we’re pretty sure the gorgeous girls of America’s number one television show are drawing their attention to the study of female anatomy.We caught up with the bombshell Kaley Cuoco last fall, and our other favorite heavenly body and this week’s woman to watch is getting some screen time as the first (and probably only) woman to ever stand up to the terrifying Mrs. Wolowitz. We sat down with our newest Femme on Fire, the beautiful Melissa Rauch, to chat about playing Bernadette, impromptu dance routines and coach factory online outlet the physical demands of playing a hooker.?? Playboy.com: So we just watched the cast and crew rock the “Call Me Maybe” mash-up (below). Where did that come from?Rauch: That was the brainchild of Kaley. Her sister choreographed it and everybody was so excited to do it. It was one of the most fun days of my life. We did two coach factory outlet hours of rehearsal the day that we shot it—it was so funny—you could look anywhere on set and everyone was secretly doing little dance moves to themselves. We want to do it every taping now. ??Playboy.com: The Big Bang Theory just hit another milestone with over 20 million viewers for last week’s episode; does this show know no bounds?Rauch: I really feel like I stepped in a big lucky pot with this job. It’s such a surreal experience, and I was a fan of the show before I joined the cast, so I was so fortunate—it feels like I won the lottery.Playboy.com: What has it been like to play Bernadette?Rauch: I love playing Bernadette! What I love about her is the unexpected—the writers do such a great job with giving Bernadette and all the characters so many different layers; there’s always something new they’ve hidden in the script for me.Playboy.com: Personality-wise, what do you share with Bernadette?Rauch: Well…we’re both on the short side. I cannot comprehend science. The fact that she’s a microbiologist is the closest I’ll ever come to making my parents proud in the realm of science academia. I know my science teachers in high school are definitely calling the bullshit alarm on me.Playboy.com: Were you a geek prior to getting cast?Rauch: I was definitely a geek in my own right. I’ve always Coach factory outlet felt comfortable around the nerd population. I wasn’t a geek in terms of the nerds we play on the show, but I was a theater geek in high school. That underdog mentality is something I definitely identify with.Playboy.com: The fandom for The Big Bang Theory is enormous. Do you ever feel overwhelmed at the conventions?Rauch: This is my second year conventions]; I lost my Comic-Con virginity after my first year as a regular, so I know what to expect now. Just getting approached by people in full costume in the most random of places…I was washing my hands in the ladies’ room and this girl in full green makeup came up and asked for an autograph. I actually coach factory outlet online had seen a hand come out from under the stall. Playboy.com: Your relationship with Howard’s overzealous mother, Mrs. Wolowitz, has become a highlight of the show; what has that been like?Rauch: I think what’s great about the relationship between Howard and his mother is that there is so much love there; I think Bernadette sees that and respects it.Playboy.com: Tell us about your new film, You Are Here.Rauch: I just did a day of shooting on that, and it was a wonderful experience. The script is phenomenal. It’s definitely a different character than Bernadette—she’s a hooker, and I don’t think Bernadette has walked the streets much in her life.Playboy.com: And you played a hooker.Rauch: I definitely have to say that some hookers are justifying to themselves why they’re doing it. I thought the clothes were really fun. She’s a high-class hooker; I don’t think I’d have the stamina to be a non-high-class hooker. I’m not saying that to be a snob; I give them a ton of credit. I think you need to be a warrior to be that. I was very warm all the time, there was no standing out on the street; I don’t think I have what it takes to work the streets… Playboy.com: At least you’re being honest, right?Rauch: I am! The next time I see a hooker walking the streets I’m going to commend her. “Good for you! You have a lot more stamina than I do.” I’m a wuss.Playboy.com: You’re also pretty great at voice impersonations.Rauch: I am, somewhat.Playboy.com: Could you do Mrs. Wolowitz for us?Rauch: Sure! Let’s see…Mrs. Wolowitz, shouts] Bernadette’s talking to Playboy.com! No daughter-in-law of mine!#8217;s note: we apologize for Coach factory outlet not being able to share this clip; it was epic.]Playboy.com: Lightning Round: What coach factory online is your favorite…City: New York—it’s still got my heart.Drink: Mojito.Food: Sushi.Shot: Chilled vodka.Embarrassing Moment: Oh brother…when I was doing standup years ago, I did an entire set with my skirt tucked up into my underwear. I had no idea. I did a solid 10 and was thinking “This audience is so weird!” As I’m walking offstage, a friend was like, “I was trying to signal you the entire time you were up there!” That was before iPhones, thankfully, because that could have been living somewhere on the internet.Guilty Pleasure: The Housewives series on Bravo…but I don’t feel guilty about it. I should probably feel more guilty about it…but I love it!Secret Talent: From my waiting table days, if a table is wobbly I’m fantastic at folding a bar napkin in such a way that it doesn’t wobble. It’s really not a classy move…I’ve dived under many tables in a skirt to do it. It makes me really excited to do it, but I really need to cool it at business dinners in the future. Pickup Line: Short guys tend to give me a pickup line with “I think we’d make a good couple.” I see the logic there, but it’s really just going in for an insult. It’s like, “we both have limited options, let’s be honest here.” But that’s not true of all short guys.Playboy.com: What was your first Playboy?Rauch: I didn’t read it, but I found in my uncle’s basement a couple boxes with vintage Playboys. The girl from Make Room for Daddy Jackson]—I remember watching her on Nick at Night, this little girl who was now in her twenties doing a spread, something about making room for daddy <>#8220;Make Room For Sherry,” 1967]. I was partially fixated on it, partially confused…then every time I watched the show I was like, “She turned into a beautiful girl!” The Big Bang Theory airs Thursdays at 8/7c. Follow Melissa on Twitter @ReallyRauch
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Charlie Seen: The Playboy

Charlie Seen: The Playboy Interview “I’m not crazy anymore,” Charlie Sheen announced this past January at the Fox Network Television Critics Association party in Pasadena, California. He said it with a chuckle, but there was an unmistakable sincerity to his confession. Usually when famous actors suffer a public scandal there are apologies and pleas for forgiveness. Not too often do they come right out and admit they went bat-shit crazy.Of course, denying his insanity might have been an exercise in futility. Few celebrities have had quite as dramatic or memorable a meltdown as Charlie Sheen. When 2011 began he was one of the highest-paid actors on TV, earning an estimated $40 million annually for starring on Two and a Half Men. And then, seemingly overnight, he went off the rails. The show took a production hiatus in late January as Sheen dealt with his public addictions to drugs, porn stars, trashing hotel rooms, etc., and during the next few months he went on a media tirade, doing increasingly erratic TV and radio interviews. He coined such catchphrases as “winning,” “tiger blood” and “Adonis DNA.” He claimed to be a warlock and a Vatican assassin who was fed up with “pretending I’m not a total bitchin’ rock star from Mars.” One minute he bragged about “banging seven-gram rocks” during a typical night of partying, and the next minute the only drug he’d admit to using was called Charlie Sheen, which he claimed normal people couldn’t take without melting their faces and causing their children to weep over their exploded bodies. He introduced the world to his “goddesses,” two girlfriends (one, Bree Olson, is a former porn star) who lived and had sex with him at his self-described Sober Valley Lodge. In March Sheen was fired by Warner Bros. for “felony offenses involving moral turpitude,” which at the time seemed to be an understatement. It took more than a year, but Sheen is finally back on TV with a new comedy, Anger Management, on the FX network. He plays a minor league baseball player turned therapist, and it will be either a triumphant return for the troubled actor or the final nail in his acting career’s coffin. We sent writer Eric -Spitznagel, who recently interviewed Jon Hamm and Craig Ferguson for -playboy, to meet with Sheen and find out whether the former tiger-blood-fueled warlock is really on the road to recovery. He reports: “After rehearsal for Anger Management wrapped, Sheen and I talked in his trailer, the infamous former party bus he’s had since Spin City, online coach factory outlet which is now decorated with crayon drawings from his children and outfitted with a fridge weirdly lacking in alcoholic beverages.“The next day, he invited me to his home in a Los Angeles gated community, just down the street from rock guitarist Slash. Once again the setting was more domestic than debauched. There was an actual apple pie cooling on the stove. ‘It’s all set dressing,’ Sheen joked. ‘As soon as you leave, all the drug paraphernalia and porn stars come out of the attic.’ Sheen made me a smoothie, spiked with nothing but strawberries. After he showed me his dad’s helmet from Apocalypse Now and we’d talked at length about baseball and why the Chicago Cubs will probably never win another World Series, we sat at his kitchen table and got down to business. During our conversation Sheen smoked so many -Marlboro Reds that even my lungs hurt.”PLAYBOY: Anger Management is the second time you play a character named Charlie, after Two and a Half Men, right?SHEEN: The third. I was Charlie on Spin City too. PLAYBOY: Is that by choice? Is it just easier for you to remember?SHEEN: I think it happens a lot in sitcoms. Jerry Seinfeld, Ray Romano and Bob Newhart all used their real first names. It’s also easier for audiences so they’re not confused by a new character. They feel they’re already familiar with me right off the bat.PLAYBOY: The Charlie you played on Two and a Half Men had a lot in common with you. How is the Anger Management -Charlie similar to you?SHEEN: He’s not. I hear that shit all the time. It’s like, Really, you want me to put my life on TV? Put it on fucking cable on Mars. “But it’s so similar!” Really? Have you ever hung out with me? Idiots.PLAYBOY: So you never draw on your personal life for your fictional life?SHEEN: Now and again there are themes that might be similar. I think that’s fine. If it’s done tastefully, it’s cool. There are times when they go too far and I’ll tell them. I’m done playing a drunken, womanizing, immature character. This time I’m playing an adult. The guy on Anger Management is professionally accomplished, a former ballplayer learning to overcome his anger issues.PLAYBOY: You went to anger therapy, right?SHEEN: I went for a year. I learned some good shit there. This may sound stupid, but it all comes down to sticks and stones. You know what I mean? Sticks and stones may break my bones——PLAYBOY: But words will never hurt me.SHEEN: Exactly. There’s so much value in that. The idea of leaving the room sometimes when you’re angry. Just leave the room! If someone follows you, go to a different room. If they keep following you, get in your car. If they follow you in your car, drive to a police station. There are ways to not engage. It’s like my dad Martin Sheen] always said: Women know what buttons to push because they helped build the machine. So every time you give in to that, you’re playing right into their hands. It’s a good point. He’s a wise man.PLAYBOY: Your dad just celebrated a big anniversary.SHEEN: His 50th wedding anniversary.PLAYBOY: How does somebody get to 50 years in a marriage?SHEEN: I have no fucking idea. PLAYBOY: Has he given you any relationship advice?SHEEN: Dad always stressed the value of the truth. He said you never have to look over your shoulder when you tell the truth. You never have to remember the details, because they are what they are. And you don’t have to make sure your story matches everyone else’s. Just tell the truth and you’re home free. If there are amends to be made, you make them. You own it and move on.PLAYBOY: Speaking of telling the truth, we should talk about last year and your whole so-called meltdown.SHEEN: Where do you want to begin?PLAYBOY: Let’s start with the basics. What the hell happened?SHEEN: I don’t know what happened. I think I cracked.PLAYBOY: Did Two and a Half Men break your brain?SHEEN: I don’t think it was the show in particular. It was the buildup of all the time I’ve been in the business, the divorces and everything. I started to unravel. I was mad about having to play the game—not that I was playing it well, but I’d been doing it for so long. I finally just said the things I had always been thinking. But in the middle of a psychotic break.PLAYBOY: Sean Penn called you a performance artist. Is it possible the whole year was one big hoax?SHEEN: That’s cool that he said that. It’s a compliment, but it’s not what was going on. I didn’t have a master plan. I didn’t realize it was going to create such a global firestorm. At the time, it felt like I was watching a lot of it from above, you know what I mean?PLAYBOY: Like an out-of-body -experience?SHEEN: Yeah. It was surreal. And it never occurred to me where this stuff was going to end up or how it was going to be perceived. I didn’t care about anything beyond the moment. And then I was a little shocked by how huge the whole thing became. It was like an organism you couldn’t stop. It kept growing.PLAYBOY: Some of the things you said will haunt you forever. “Winning” is now part of the pop-culture lexicon.SHEEN: I guess so. You know what’s interesting about that? It’s stated in the present tense. We were in the act of winning. It was current. It wasn’t “We’ve won” or “We’re going to win.”PLAYBOY: It was an coach backpacks active verb.SHEEN: Exactly. PLAYBOY: Is that why people connected with it so much?SHEEN: That’s part of it. The economy was in the toilet and people were dealing with their horrible bosses. So they were like, “Oh, here’s a guy who stood up to his boss, who had the balls to say, ‘Fuck it, you’re wrong, I’m right.’?”PLAYBOY: You kept insisting you were winning when everything that was happening in your life and career at the time seemed like the complete opposite of winning.SHEEN: Absolutely. I was in total denial. PLAYBOY: Was it just positive thinking? If you say you’re winning enough times, maybe things will turn around?SHEEN: It wasn’t that bleak in my head. I felt I was winning by finally being able to speak my mind. I felt that was some sort of victory. And then it was fueled by the insane public outpouring of support.PLAYBOY: Not only were you winning, but you called yourself a warlock.SHEEN: I didn’t know what the hell a warlock was; I just liked the way it sounded. It’s got war in it; it’s got a kah sound. War-lock. Remember the Salem warlock society? They were going to cast a hex on me.PLAYBOY: Because you were making a mockery of their religion?SHEEN: Something like that. I was hurting the warlock name. I was like, “Bring it on! I’ll eat your hex for breakfast.” It’s so fucking stupid. I’m in a beef coach backpacks with a warlock society? You’re kidding me, right? How do you go from making Oliver Stone movies to being in a feud with warlocks?PLAYBOY: The list goes on and on. Tiger blood, Adonis DNA, you’re on a drug called Charlie Sheen.SHEEN: Most of it came out of nowhere. It wasn’t planned, it was just random. The tiger blood? I don’t know. It’s just a very dangerous animal. And there’s a tiger in Apocalypse Now, by the way, so maybe there’s a connection there. Adonis DNA? I cheap coach backpacks don’t know what the fuck that was about. That was just stupid. That went a http://www.ccoachfactoryoutlets.com/ little far.PLAYBOY: You made a lot of allusions to war during that period, especially when talking about Two and a Half Men creator Chuck Lorre and CBS. Did it feel as though you were in a literal war?SHEEN: It felt like combat, yeah. I don’t know what real combat feels like, but it felt like emotional combat, like spiritual combat. One thing I can’t tolerate is being disrespected. Fuck that. I’m talking about literal, genuine examples of coach factory disrespect, where you feel unappreciated. Guys want to be respected and acknowledged. They want to feel what they contributed matters. I felt I contributed a lot, and suddenly it didn’t matter.PLAYBOY: Why would CBS and Lorre change their minds about you?SHEEN: Because they read things about me and believed them. They were like, “He’s crazy” or “He’s drunk” or “He’s fucked-up” or “He’s a fucking weirdo” or whatever. But if you’re special, you’re tortured. I know that sounds arrogant, but you can’t not be special and have a 30-year career. You can’t not be a little different from others and be successful for three decades. Your mind has to work a little differently than the average brain. But here’s the good news. I’m not there anymore. I’m not working with CBS or Warner Bros. or Chuck anymore. Good news for them and good news for me.PLAYBOY: Did you ever enjoy yourself on Two and a Half Men?SHEEN: The early stuff was fun. It was fresh, and we were still kind of finding our way. The first time and a Half Men co-star] Jon Cryer and I read together, it was magic. No question.PLAYBOY: How is your relationship with Jon these days?SHEEN: I don’t have one.PLAYBOY: You said some cruel things about him last year. You called him a troll and a traitor. Was that the heat of the moment, or did you really feel that way?SHEEN: That was wrong. I whaled on him unnecessarily.PLAYBOY: But at the time did you feel he should have defended you?SHEEN: I made a mistake. But yes, I felt he should have come forward with some kind of support. But says who? What rule book is that written in? It’s not. He was trying to keep the shit together, trying to cover my ass, pick up the slack. He just got caught in the crossfire. He’s a beautiful man and a fucking fabulous dude and I miss him. I need to repair that relationship, and I will. I will reach out and do whatever is necessary.PLAYBOY: Looking back on it a year later, do you have a better understanding of what went wrong, why you lost Two and a Half Men?SHEEN: I know exactly what went wrong. CBS and Warner Bros. were in breach. That’s it. That’s why this thing never went to any kind of arbitration. They knew they’d have to admit they screwed up. They were too involved in their own egos and their own emotions. I guess that’s why I went full-court press on them, because I knew they didn’t have a case. My job was to show up and act; their job was to write. Or it was someone’s job to write, and Chuck Lorre decided he wasn’t going to do it anymore.PLAYBOY: They would probably claim it had more to do with your drug problems.SHEEN: That was a fucking hernia, by the way.PLAYBOY: What was?SHEEN: In January, before I got fired, when I went to the hospital. The hernia was real. Everybody thought I had OD’d or whatever. No, I had a fucking hernia blow out of my stomach. I called the paramedics, because that’s what you do, right?PLAYBOY: There were tabloid reports that you had a suitcase of cocaine delivered to your house.SHEEN: That’s such bullshit. And that’s what I got fired over. I didn’t get fired for the Plaza Hotel thing he was accused of assaulting a porn star]; I didn’t get fired for the Vegas bender. I got fired for a hernia. And it’s real. Check it out. up shirt] See that? out stomach and points to hernia scar] It’s there. I didn’t get it fixed because I thought we were going to court and I would have to show this from the stand.PLAYBOY: There were rumors that the hernia happened after several days of constant partying and drugs.SHEEN: No, that’s just not true. It was because of a Dave Chappelle sketch.PLAYBOY: Oh, come on.SHEEN: Remember that scene where he’s a blind white supremacist who doesn’t know he’s black? Have you seen it? It’s the funniest thing in the world. He becomes a Klansman, and he’s railing against black people. It’s insanely brilliant. 123Next
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How the innovation in the MLB

How the innovation in the MLB might mean moving backwards I’m sitting in what a city-slicker might call the back 40, the 500-level seats, complete with the broad iron brandishing of steel girders supporting a roof that retracts, opening on occasion to release all the trapped echoes held within this monstrous dome. I can literally touch the walls of this cold alien world and look out upon its neon green ecosystem, a replica field with little tiny players playing a little tiny game. The air up here is different: it’s more dense, noxious, cycled through a complicated series of fans and filters and released back into our lungs. The sounds are softer, dulled by all the dead air. Up in the far reaches of the Rogers Centre there is no telling sound to signal the discord of a hit in a once-perfect game: that cacophony is lost. The alarming crack of a bat, the slap of leather on leather, even the once-raucous roars of the crowd circa the early nineties (alive again, I must say) are reduced to little more than a dull thud in this cordoned-off, covered and cavernous space. You’re removed; all the tight-knit, anxiety-inducing, close-quartered encounters that make a ballpark infuriating and at the same time alive and intimate are gone. Amid the dead gray of a concrete mass and the cracking, chipped blue walls of the once-infamous SkyDome, a game that is usually so personal, so close and so real seems less so. Somehow it seems less alive. Less human.Back in the late ’70s and all through the ’80s, baseball stole out from under the summer skies and moved indoors. The reason was twofold: it was a game repeatedly subject to whims of weather and being supplanted in cities with hostile climates, cities like Seattle and Tampa Bay that simply couldn’t support a team whose games always had a 50/50 chance of being rained out. In places like Montreal, Minnesota and Toronto, moving indoors made sense if the teams were ever to play in October, when precipitation more often than not meant snow. It just made sense. We’d learned long ago how to weather a storm; so too, we figured, should our national pastime.The second reason for the retreat was financial: moving into monstrous stadiums, stadiums already in place or at least in the planning stages, made sense if multiple teams could play in them and in turn cut the cost. Having the Seahawks, the SuperSonics and the Mariners all sharing space in the Kingdome meant year-round revenue at a third of the cost it would take to build three separate venues. Again, it just made sense. But what a financial or weather report could never factor in, what it had no graph for, was the impact moving into these hulking monstrosities would have on the game. For football, it was fine; you could fill the stadium and no one was any the wiser. Ditto basketball, whose fans were born and bred in the rafters, already used to the game being coach backpacks played indoors. But for baseball, a slower game attended in equal parts for the sport and the experience, the Kingdome, the Hubert Coach Outlet Online Humphrey Metrodome, SkyDome and Tropicana Field were cold, dead places, places that lacked intimacy or a feel for the game, Frankenstein’s monsters born to resemble a baseball field but whose dimensions were skewed and cold to the touch. These stadiums, however practical on paper, just couldn’t complement the experience; they complicated it.And so fans revolted: to this day the four parks mentioned above, some no longer standing, still rank among the worst venues to watch a baseball game. They sucked the sunlight and soul from the seats. There was nothing appealing about wasting away an afternoon on a concrete slab under an overly fake fluorescent sun. Today, only three parks remain that can be described, architecturally, as “multipurpose”: the Rogers Centre, the Trop and the ungodly eyesore of the Oakland-Alameda County Coliseum. The rest, primarily built, rebuilt or renovated in the ’90s or early 2000s in a movement we’ll call reactionary, a return to whatever it was we found in the sun, are best described as “retro classic,” “retro modern” or “retro modern classic.” That, of course, is not to say that they’re all ideal (or that we care to distinguish between “retro classic” and “retro classic modern”); Busch Stadium is still an expansive football-fieldesque chasm, Chase Field is more akin to the basement pit in Silence of the Lambs and the new Marlins Park in Miami is a contemporary spastic circus of poor sightlines and scenery. But they are all more alive. They are more in tune with the game, closer to recapturing the experience of the ballpark, of breathing life, literal un-cycled air back coach backpacks into the afternoon.And yet after almost two decades of staring at dead space, we find ourselves on the precipice of another monster threatening the humanity of a game we just took back from the cold clutches of modernity, rescued from the dehumanizing qualities of a crass, concrete world. Here we are welcoming the possibility of instant replay, of a strictly defined strike zone upheld by an army of robotic umpires with laser-like accuracy and not an ounce of give. Ominous, always-right overlords without a drop of humanity.Prompting this discussion is a recent strange series of blown calls: an obvious safe call botched by Tim Welke, back-to-back balls called strikes by Bill Miller, last year’s 19-inning mess at home in Atlanta and of course Armando Galarraga’s and R. A. Dickey’s not-so-perfect games.But as infuriating as a blown call might be, as important as a two-out, 3-2 bases loaded ball that should have been a strike might be to the pitcher, the human element remains as much an integral part of baseball as the bat or the ball or the park. It’s what keeps us coming back; it’s what drives fans to fury. It does occasionally backfire, at times it is grossly unfair, but it is what keeps the fans connected to the play on the field. In the same way that the colossal stadiums of yesteryear moved us both figuratively and literally further away from the game, the introduction of what will undoubtedly be overused replay or worse, the reduction of the strike zone to systematic science, threatens the very lifeblood of the game.Long gone would be the days of Lou Piniella waddling in a huff to home plate. No more ejections or irrational implosions on the mound by a pitcher still fuming over an inside corner that was actually a ball. No more arguments coach backpacks between friends at the bar over high strikes and slow looping curves. No more questioning safe at second, out at third or dead to rights at home. It would all boil down to a science, a little red blip, a flashing little battery-controlled robot that’s always right but in the end would be profoundly wrong. This is the argument of purists. The argument for the presence of human error in a game of measured skill can only be a purist one in the sense that the game remains as close to its roots as possible, not that it is free from error. It comes from the mouths of the same people who found it uncomfortable, disconcerting to watch baseball in a dome under the ever-present and unnatural glow of fluorescent bulbs. From the people who gather around the water cooler at work to talk baseball, to dissect last night’s game down to the last pitch. For them, baseball, with all its blown calls, its crumbling but storied walls, its retro modern feel free from whatever architectural flight of fancy might be the choix du jour, baseball, with Coach Outlet all its imperfections, is perfect.
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20Q CHRIS HARDWICK

20Q CHRIS HARDWICK Q1PLAYBOY: Your podcast, called Nerdist, gets 4 million downloads every month. Are podcasts the future of comedy or just something to do while you wait to get cast in a sitcom?HARDWICK: I do podcasts for the same reasons I do stand-up comedy. I love it, and I don’t care if anybody else gets it. I don’t know if the podcast as a medium will ever have the cultural impact that TV and movies do. It may never be super-mainstream. For some people, you say podcasts and they’re like, “What the hell is that?” They don’t understand it’s like a radio show you can download. Mainstream culture is like your mom: It’s always a little late to catch on and gets easily confused by technology, but it means well.Q2PLAYBOY: What exactly is a nerdist? Is it just a fancy word for nerd? HARDWICK: I think the Urban Dictionary defines nerdist as “an artful nerd.” That’s not bad. It’s on the safe side of pretentious. Nerdists, unlike nerds, tend to be creators as much as consumers. They’re creative consumers. They don’t just sit and watch passively. They’re crafty. They make shirts and posters and confectionery things.Q3PLAYBOY: Nerds have been around since the dawn of time. Why are they getting respect now?HARDWICK: Because nerds make money. I hate to say it, but because of humanity’s capitalistic nature, money is important. And with money comes power. I think it’s also about accessibility. So many people of this current generation have grown up with technology and video games, it’s not nerdy to like that kind of stuff anymore. Nerd culture is ubiquitous.Q4PLAYBOY: Nerdist Industries is the name of your media empire of websites, podcasts and YouTube videos. In what ways are you similar to ruthless 19th century industrialist George Pullman?HARDWICK: In every way. I’ve always had a fondness for that satirical, Terry Gilliam–esque evil corporate megastructure, the kind of business that hangs banners that say making your life better as it throws kittens into the gears. I want Nerdist Industries to be like that. For a while we were using the slogan “Nerdist: Making Today the Yesterday of Tomorrow,” which is just stupid. It’s dumb doublespeak. But the whole idea of being an industry is about making fun of people’s confusion.Q5PLAYBOY: You were born in Kentucky and raised in Tennessee, but you don’t have even a trace of a Southern accent. Do you consider yourself a Southerner?HARDWICK: I love the South. Although I grew up primarily in Memphis, my family moved around a ton when I was a kid. I guess I never stayed in one place long enough to pick up the accent, but I definitely identify as a Southerner. I fucking love grits, for one thing. I am a grits-eating motherfucker. I love all Southern cooking—collard greens, black-eyed peas, I’ll eat it all. Put me in the kitchen and you’ll see how Southern I can be.Q6PLAYBOY: Your father is a retired professional bowler. Were you ever pressured to go into the family business?HARDWICK: Absolutely not. Both my parents recognized early on that I wanted to do something in comedy, and they were really supportive. They’re the ones who bought me Steve Martin records and let me watch R-rated comedies long before they probably should have. But I still spent a lot of time bowling as a kid, mostly because I grew up in bowling alleys. They were kind of my playgrounds. Not only was my dad a pro bowler, but my mother’s father and brother both owned their own bowling centers. I still bowl today, though I wouldn’t recommend doing it with me. I’m not fun to bowl with, believe me. I take it way too seriously.Q7PLAYBOY: How did you discover your nerd tendencies growing up in a bowling alley? It’s not a nerd-friendly environment.HARDWICK: It can be. That’s where I got into arcade games. My grandfather, my mom’s dad, who was a really smart and wonderful man, was a technophile. He was the first guy to buy those big laser-disc players in 1979. He had the latest camcorders and stereo systems and Betamax players. He noticed early on that video games were a big deal, so he set up a massive arcade in his bowling center in Florida. I spent all my time there. When I wasn’t playing video games, my friends and I would play Dungeons & Dragons or chess at the bar. I had full access to all my nerd obsessions. I guess when I think about it, I was a spoiled piece of shit.Q8PLAYBOY: You’re not a fan of competitive athletic sports. As a spectator or a participant?HARDWICK: Neither. I don’t think there’s anything inherently wrong with sports; I just don’t give a shit. When I see dudes in sports bars shoving chicken wings in their faces, watching a game and saying, “That’s my team,” it mystifies me. I’m like, You’re sitting on your fat ass. What are you doing that makes you a contributing member of the organization? You’ve lifted nothing but drumsticks for the past three hours.Q9PLAYBOY: Have you considered joining a fantasy league? They have statistics and math, all the nerd staples.HARDWICK: Yeah, that’s not a bad idea. I would have to look at it like a chess game, as a strategy. If I did that, I could probably find a way in. It would make my life a lot easier if I could find a way to appreciate sports. I mean, I’ve never watched an entire football game. It’s horrifying. So many dudes try to bond with me over sports. They’ll come up to me and say, “Hey, do you know the score of the game?” I won’t even know what to say. Game? What game? I can give you some quotes from the last Harry Potter movie. Does that help?Q10PLAYBOY: You majored in philosophy at UCLA. Were you just not interested in making money or having a career?HARDWICK: Steve Martin, my comedy idol, was a philosophy major in college. He once said that philosophy is a great thing for comedians to study because it screws up your thinking just enough. If you’re going into stand-up, you’re hyper-analyzing the world and asking as many questions about a thing as you possibly can so you can figure out the ultimate nature of that thing. If you want to get into comedy, it’s really the only subject worth studying.Q11PLAYBOY: Your first big career break was as a co-host with Jenny McCarthy on the MTV dating show Singled Out. Which leads to the obvious question——HARDWICK: No, I did not fuck Jenny McCarthy.Q12PLAYBOY: Actually, that’s not what we were going to ask, but thanks for clearing that up. We were wondering if hosting the show taught you any big life lessons about dating.HARDWICK: For me, the lessons of Singled Out weren’t about dating. They were about fame. I learned that just being on MTV doesn’t make you famous. When I got the job, I was like, Oh man, I’m going to be on a private jet with fucking Kurt Cobain. We’ll be toasting martinis and getting blown by mermaids. And of course none of that happened. The show ended, and I became an out-of-work comic with a drinking problem.Q13PLAYBOY: Is it true that Jon Stewart mocked you into sobriety?HARDWICK: In a way. I was in my apartment, watching The Daily Show, and McCarthy was a guest. Stewart made a joke about me. Somehow my name came up, and Stewart was like, “He gets our coffee now.” It devastated me. It was the first moment I took a long hard look at my life and my career. It made me realize, Oh my God, I’ve become that MTV stereotype I always worried about becoming. I was proud of Jenny, and I say that with no bitterness. There are only a handful of people who started their careers on MTV who managed to keep it going. There’s Jenny and Pauly Shore and maybe a few others. But it never happened for me. I became the washed-up drunk loser with floppy hair who used to be on a dating show.Q14PLAYBOY: How did you dig yourself out of that hole?HARDWICK: When I look back, every time I felt something bleak was happening with my career, I would make some sort of survival-based choice, doing something I could control. I was very lazy about doing stand-up when I was hosting Singled Out. I was like, “Whatever, I have a job.” But when I had nothing, it was a lifeline. It made me feel coach factory outlet I was finally taking control of my career. The same thing with the podcast. Every time I was rejected by the entertainment business, which was a lot, I’d be like, “Well, fuck you. herve leger dresses I’m going to do my own thing.” Even if nothing happened with it, it was my thing and they couldn’t touch it. Of course, the business didn’t give a shit at the time, but I was still muttering under my breath like a crazy person.Q15PLAYBOY: You wrote a self-help book called The Nerdist Way: How to Reach the Next Level (in Real Life). Are you better at giving advice or taking it?HARDWICK: It’s so much easier to give advice than to take it. But I tend to trust any advice that comes from years of fuck-up research. When I was younger, my parents used to say, “Trust us on this. We have more experience than you.” And I was like, “Shut up, you don’t know anything!” But I was an idiot. They did know more stuff because they’d experienced more things. They’d fucked up more often than I had. There’s no better path to knowledge than fucking up. coach factory outlet Q16PLAYBOY: You were part of a regular Dungeons & Dragons game with comedians Brian Posehn, Patton Oswalt and others. Why are comics drawn to fantasy role-playing games?HARDWICK: I really don’t know. Maybe because D&D is the perfect mental exercise. It’s math and fantasy. It’s statistics and Lord of the Rings. It requires you to use your mind but also be social. Our game was amazing just because everyone involved was so goddamn funny. Patton had a drunken dwarf character called Stump Hammer. I was a lawful good wizard named Blaividane, sort of an anagram of David Blaine’s name. Brian had a ninja character who was obsessed with pickles. It was some of the best times I’ve ever had playing D&D. I really miss it.Q17PLAYBOY: You don’t play anymore?HARDWICK: The bummer thing about a D&D game is that it’s like having a band. If one coach factory outlet person can’t show up, then the whole thing falls apart. Our game ended because our dungeon master got a girlfriend, and she didn’t want him playing D&D on Sundays with a bunch of guys for five hours. We’d run into him later, and it was always awkward. It was like we were a dude and he was our ex-girlfriend.Q18PLAYBOY: You’re a regular at Comic-Con in San Diego. Are we correct in thinking it’s like Plato’s Retreat with Spock ears? HARDWICK: There is an element of that, yeah. Hey, nerds made porn available on the internet—what else do you need to know? But that’s the vibe at comic book conventions in general. When I was growing up, nerds had this reputation for being virgins who lived in their parents’ basements. That’s certainly not the case now. I would say that nerds, as a rule, are much more sexually active than the average person. There’s a lot of anxiety and stress in the nerd brain, so sex is good for that.Q19PLAYBOY: You’re a Star Wars fanatic. Isn’t your girlfriend, Chloe Dykstra, part of Star Wars royalty?HARDWICK: In a way, yeah. Her dad did the effects for Star Wars. He helped develop the technology for the lightsaber. The freaking lightsaber! I’m not saying that’s why I go out with her, but it’s definitely a big check in the “pro” box. A couple of months herve leger dresses ago she brought me this gift bag, and she was like, “Yeah, I was just rifling around my dad’s garage.” It was an original Star Wars crew T-shirt, with a design I’d never seen before, and an original Star Trek: The Motion Picture crew shirt. It was the best gift I’ve ever gotten. I went on a tour of Skywalker Ranch a couple of years ago and saw the original everything—the original droids, the original concept art, the original lightsabers. I saw the original Yoda, and I’ll be honest, I wanted to spoon with him.Q20PLAYBOY: As a card-carrying nerd, this is probably the most important question you’ll ever be asked. If and when you have kids, how will you introduce them to the Star Wars movies? In what order?HARDWICK: You’re not kidding about it being an important question. I talk about this a lot. It’s a big moral quandary. Do you want your kids to experience it like you experienced it, or do you go in the proper order? I’ve heard arguments on both sides. The problem with doing it in numerical order is that it ruins the Vader “You are my father” surprise. The most convincing case I’ve read was by herve leger dress this guy Rod Hilton, who came up with something called the Machete Order. He recommends showing them like this: A New Hope, then Empire, then Attack of the Clones, then Revenge of the Sith, then Return of the Jedi, completely leaving out Phantom Menace. His point is Phantom is unnecessary, and parts two and three play like a flashback. It makes sense, but I still don’t know. I saw Star Wars in the theater with my dad, so if I had a kid, I’d maybe want to show the movies to him or her in that order, just for the tradition of it. I don’t know. This is too much pressure. It’s like asking where I want to be buried. Can I get back to you?
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Conti brought about the data

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Celebrity Interview with The

Celebrity Interview with The Big Bang Theory's Melissa Rauch Unless you’ve been living on another planet for the past six years, you or someone you know is likely glued to their television sets each week as the greater cosmos is explained by the quirky nerds of CBS’s The Big Bang Theory.When audiences aren’t scratching their heads trying to make sense of the asexual Sheldon Cooper’s way of life, we’re pretty sure the gorgeous girls of America’s number one television show are drawing their attention to the study of female anatomy.We caught up with the bombshell Kaley Cuoco last fall, and our other favorite heavenly body and this week’s woman to watch is getting some screen time as the first (and probably only) woman to ever stand up to the terrifying Mrs. Wolowitz. We sat down with our newest Femme on Fire, the beautiful Melissa Rauch, to chat about playing Bernadette, impromptu dance routines and coach factory online outlet the physical demands of playing a hooker.?? Playboy.com: So we just watched the cast and crew rock the “Call Me Maybe” mash-up (below). Where did that come from?Rauch: That was the brainchild of Kaley. Her sister choreographed it and everybody was so excited to do it. It was one of the most fun days of my life. We did two coach factory outlet hours of rehearsal the day that we shot it—it was so funny—you could look anywhere on set and everyone was secretly doing little dance moves to themselves. We want to do it every taping now. ??Playboy.com: The Big Bang Theory just hit another milestone with over 20 million viewers for last week’s episode; does this show know no bounds?Rauch: I really feel like I stepped in a big lucky pot with this job. It’s such a surreal experience, and I was a fan of the show before I joined the cast, so I was so fortunate—it feels like I won the lottery.Playboy.com: What has it been like to play Bernadette?Rauch: I love playing Bernadette! What I love about her is the unexpected—the writers do such a great job with giving Bernadette and all the characters so many different layers; there’s always something new they’ve hidden in the script for me.Playboy.com: Personality-wise, what do you share with Bernadette?Rauch: Well…we’re both on the short side. I cannot comprehend science. The fact that she’s a microbiologist is the closest I’ll ever come to making my parents proud in the realm of science academia. I know my science teachers in high school are definitely calling the bullshit alarm on me.Playboy.com: Were you a geek prior to getting cast?Rauch: I was definitely a geek in my own right. I’ve always Coach factory outlet felt comfortable around the nerd population. I wasn’t a geek in terms of the nerds we play on the show, but I was a theater geek in high school. That underdog mentality is something I definitely identify with.Playboy.com: The fandom for The Big Bang Theory is enormous. Do you ever feel overwhelmed at the conventions?Rauch: This is my second year conventions]; I lost my Comic-Con virginity after my first year as a regular, so I know what to expect now. Just getting approached by people in full costume in the most random of places…I was washing my hands in the ladies’ room and this girl in full green makeup came up and asked for an autograph. I actually coach factory outlet online had seen a hand come out from under the stall. Playboy.com: Your relationship with Howard’s overzealous mother, Mrs. Wolowitz, has become a highlight of the show; what has that been like?Rauch: I think what’s great about the relationship between Howard and his mother is that there is so much love there; I think Bernadette sees that and respects it.Playboy.com: Tell us about your new film, You Are Here.Rauch: I just did a day of shooting on that, and it was a wonderful experience. The script is phenomenal. It’s definitely a different character than Bernadette—she’s a hooker, and I don’t think Bernadette has walked the streets much in her life.Playboy.com: And you played a hooker.Rauch: I definitely have to say that some hookers are justifying to themselves why they’re doing it. I thought the clothes were really fun. She’s a high-class hooker; I don’t think I’d have the stamina to be a non-high-class hooker. I’m not saying that to be a snob; I give them a ton of credit. I think you need to be a warrior to be that. I was very warm all the time, there was no standing out on the street; I don’t think I have what it takes to work the streets… Playboy.com: At least you’re being honest, right?Rauch: I am! The next time I see a hooker walking the streets I’m going to commend her. “Good for you! You have a lot more stamina than I do.” I’m a wuss.Playboy.com: You’re also pretty great at voice impersonations.Rauch: I am, somewhat.Playboy.com: Could you do Mrs. Wolowitz for us?Rauch: Sure! Let’s see…Mrs. Wolowitz, shouts] Bernadette’s talking to Playboy.com! No daughter-in-law of mine!#8217;s note: we apologize for Coach factory outlet not being able to share this clip; it was epic.]Playboy.com: Lightning Round: What coach factory online is your favorite…City: New York—it’s still got my heart.Drink: Mojito.Food: Sushi.Shot: Chilled vodka.Embarrassing Moment: Oh brother…when I was doing standup years ago, I did an entire set with my skirt tucked up into my underwear. I had no idea. I did a solid 10 and was thinking “This audience is so weird!” As I’m walking offstage, a friend was like, “I was trying to signal you the entire time you were up there!” That was before iPhones, thankfully, because that could have been living somewhere on the internet.Guilty Pleasure: The Housewives series on Bravo…but I don’t feel guilty about it. I should probably feel more guilty about it…but I love it!Secret Talent: From my waiting table days, if a table is wobbly I’m fantastic at folding a bar napkin in such a way that it doesn’t wobble. It’s really not a classy move…I’ve dived under many tables in a skirt to do it. It makes me really excited to do it, but I really need to cool it at business dinners in the future. Pickup Line: Short guys tend to give me a pickup line with “I think we’d make a good couple.” I see the logic there, but it’s really just going in for an insult. It’s like, “we both have limited options, let’s be honest here.” But that’s not true of all short guys.Playboy.com: What was your first Playboy?Rauch: I didn’t read it, but I found in my uncle’s basement a couple boxes with vintage Playboys. The girl from Make Room for Daddy Jackson]—I remember watching her on Nick at Night, this little girl who was now in her twenties doing a spread, something about making room for daddy <>#8220;Make Room For Sherry,” 1967]. I was partially fixated on it, partially confused…then every time I watched the show I was like, “She turned into a beautiful girl!” The Big Bang Theory airs Thursdays at 8/7c. Follow Melissa on Twitter @ReallyRauch
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Conti brought about the data

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