Zarife Sahenk

After a single injection, mice with a disease resembling type 1A Charcot-Marie-Tooth showed  improved strength and nerve signaling

posted on April 21, 2010 - 3:49pm
Mice with a disorder resembling type 1A Charcot-Marie-Tooth (CMT1A) disease that received a single intramuscular injection of genes for the protein neurotrophin 3 (NT3) showed improvements in grip strength, ability to stay on a rotating rod, and strength of nerve signals, investigators reported April 15, at the 2010 meeting of the American Academy of Neurology, held in Toronto.

Neurotrophin 3 genes strengthened mice with a disease resembling CMT1A

posted on May 18, 2009 - 5:29pm
Zarife Sahenk at Nationwide Children's Hospital and Ohio State University in Columbus, and colleagues, found mice with a disease resembling type 1A Charcot-Marie-Tooth disease (CMT) benefited from a transfer of genes for the neurotrophin 3 protein. CMT1A is caused by a duplication of the PMP22 gene. Jerry Mendell, who has received many MDA research grants and co-directs the MDA clinic at...