valproic acid

Valproic acid and carnitine didn't help nonwalkers with SMA who were 2 to 8 years old

posted on February 13, 2009 - 1:31pm
Preliminary results in the phase 2 study of valproic acid and carnitine in children with types 2 and 3 spinal muscular atrophy (SMA) suggest the treatment may have improved function in children younger than age 3 who were not walking at study entry. However, there was no benefit of the drug treatment when a larger group that included children ages 2 to 8 who were not walking was compared with a...
posted on September 1, 2006 - 3:11pm
QUEST Vol. 13, No. 5
Valproic acid improves strength in SMA study The drug valproate (valproic acid), currently used for seizures, bipolar disorder and migraine headaches, increased ob-jective and subjective strength assessments in six adults with type 3 or 4 spinal muscular atrophy (SMA). Laboratory experiments have suggested that valproate can increase the level of full-length SMN protein molecules, needed but...