Tom Misteli

Lamin defects may disrupt nerve-muscle signals in Emery-Dreifuss MD

posted on January 28, 2009 - 6:16pm
Mutations in the lamin A/C gene on chromosome 1 and the emerin gene on the X chromosome both can cause Emery-Dreifuss muscular dystrophy (EDMD), but the precise mechanisms by which they do so are still being identified. Now, a multinational team has found that, in mice with an EDMD-like disease, lamin protein defects interfere with the way cell nuclei normally localize in skeletal-muscle fibers...

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