TDP43 mouse

ALS TDI's May 2010 research update addressed changes: a new mouse model, new projects, a paradigm shift and a model for faster drug development

posted on June 1, 2010 - 12:33pm
In its quarterly Research Update Webcast on May 18, 2010, the ALS Therapy Development Institute (ALS TDI) informed viewers of a "paradigm shift" in TDI research. The changes include the addition of a new mouse model to the Institute's preclinical drug development program and an increased emphasis on the importance of biological indicators called "biomarkers."  The webinar also addressed the...

A new type of ALS research mouse, with a mutation in the TDP43 gene, has been developed

posted on October 8, 2009 - 9:00pm
Mice carrying a mutation in the gene for the TDP43 protein that's known to cause amyotrophic lateral sclerosis (ALS) in humans have been developed by MDA-supported scientists at Washington University School of Medicine in St. Louis. The mice may provide an important new research tool in this deadly disease.