A trial of a drug that reduces testosterone levels did not improve swallowing in men with spinal-bulbar muscular atrophy

posted on August 30, 2010 - 12:51pm
 Reducing testosterone levels in a large-scale trial in men with spinal-bulbar muscular atrophy (SBMA, or Kennedy disease) did not significantly affect swallowing function, despite earlier indications that it might improve this aspect of the disease.
posted on October 1, 2009 - 3:52pm
QUEST Vol. 16, No. 4
Seattle resident Ken Lang (see “Like a Frog”) says he knew a disease that impairs swallowing and speaking was a possibility for him, because his father, uncle and grandmother had been affected by such a disorder.
posted on October 1, 2009 - 3:29pm
QUEST Vol. 16, No. 4
During the holidays, eating is as much about friends and family as it is about food. But when muscle weakness makes it difficult or impossible to eat by mouth, some shy away from coming to the table. Nonsense, say those who’ve learned how to work around — or ignore — the social discomfort. Life’s too short to miss out on the fun. Below are adapted dining tips from therapists and people with weak...
posted on October 1, 2009 - 3:27pm
QUEST Vol. 16, No. 4
Ken Lang’s OPMD symptoms began with swallowing problems, when he was about 50. “They were fairly mild at first,” he says. “There were certain foods I could no longer eat,” such as rice and ground beef. “I couldn’t eat a hamburger. I couldn’t swallow it. It would get stuck. I’d have to cough it up, or I’d feel a sensation of choking. Over the course of time, the symptoms got a little worse, and my...
posted on October 1, 2009 - 3:18pm
QUEST Vol. 16, No. 4
Starting with the tongue and moving down the throat and into the esophagus are a series of muscles that constrict and push food from the mouth to the stomach. The tongue and throat muscles weaken severely in OPMD, leading to choking, inhaling food into the lungs (“aspiration”) and lung infections (pneumonia). Speaking also can be adversely affected by weakening tongue and throat muscles. 
posted on October 1, 2009 - 1:04am
QUEST Vol. 16, No. 4
Fast Facts OPMD is a form of muscular dystrophy in which symptoms usually first appear between the 30s and 60s, and primarily involve the muscles of the upper eyelids and the swallowing muscles. As these muscles weaken, patients have difficulty keeping their eyes open and find that food and liquids are increasingly hard to swallow. As OPMD progresses, it can weaken the muscles of the limbs,...
posted on September 1, 2008 - 9:32am
QUEST Vol. 15, No. 5
This article includes items about: myotonic dystrophy type 1, myotonic dystrophy type 2, spinal muscular atrophy, spinal-bulbar muscular atrophy