stem cells

In a podcast from Nationwide Children’s Hospital, longtime MDA grantee Jeffrey Chamberlain describes advances in gene transfer therapy and stem cell therapy for Duchenne muscular dystrophy

posted on July 31, 2013 - 3:31pm
In a July 2013 podcast from Nationwide Children’s Hospital in Columbus, Ohio, longtime MDA grantee Jeffrey Chamberlain discusses recent advances in the development of gene therapy (gene transfer) and stem cell therapy (transplantation) for Duchenne muscular dystrophy (DMD), the results of which may apply to other types of muscular dy
posted on January 1, 2012 - 1:42pm
QUEST Vol. 19, No. 1
Stem cells have been much in the news lately, including for neuromuscular diseases. One extremely promising approach has been to create stem cells from the adult (differentiated) cells of humans or animals, and then reprogram them back to a stemlike state, after which they can be redifferentiated into a desired cell type, such as muscle or nerve cells. Stem cells made from differentiated cells...

Several recent studies have found that the stem cell 'reprogramming' processes can lead to dangerous abnormalities

posted on September 20, 2011 - 10:52am
Stem cells have been much in the news lately, including for neuromuscular diseases.

Quest takes a look at gene therapy, 'antisense' and other cutting-edge scientific approaches and how they're being applied to diseases in MDA's program

posted on July 1, 2011 - 4:15pm
QUEST Vol. 18, No. 3
Antisense oligonucleotides block flawed genetic instructions Antisense oligonucleotides — also called antisense, oligos, or simply AONs — are pieces of genetic code that keep other genetic code from being processed. Designed to pair up with a particular sequence of DNA or RNA, AONs can change, block or destroy targeted genetic instructions in a variety of ways.

Progress is ongoing in coaxing stem cells along specific paths, altering their genes and understanding the immune response to stem cell transplantation

posted on June 13, 2011 - 2:23pm
Stem cells are a hot topic these days in medicine, science and law, although the term has multiple meanings and it's easy to get confused. In short, stem cells are cells at an early stage of development from which specialized cells, such as muscle or nerve cells, can develop (in other words, from which these specialized cells "stem"). Different kinds of stem cells are referred to as:

Brief items about myostatin inhibition, exon skipping and stem cell research in Duchenne muscular dystrophy

posted on October 20, 2010 - 9:45am
Anti-myostatin drug trial shows good preliminary results

MDA-supported scientists in Ottawa have found that controlled damage to DNA is required before immature muscle cells can mature into muscle fibers.

posted on February 23, 2010 - 9:48am
Remodeling a building usually requires some degree of dismantling before new construction can begin. That principle, it now seems, also may apply to the remodeling of the body's cells.  Scientists at Ottawa Hospital Research Institute and the University of Ottawa have found recently that it applies to muscle cells, which can only develop from a stemlike state into mature muscle fibers after...

An ALS Therapy Development Institute Webcast summarizes research progress as of July 2009

posted on July 29, 2009 - 12:15pm
On July 16, 2009, the MDA-supported ALS Therapy Development Institute (ALS TDI) gave its quarterly research update in a Webcast that's now archived on the Institute's site and accessible to all who register. (See Research Update Q209.)