split gene strategy

posted on March 1, 2007 - 2:34pm
An MDA-supported research team, testing gene transfer in dogs using adeno-associated viral (AAV) shells (vectors), noted an unwanted immune response, a factor they recommend be considered in human trials. The response occurred even when the vectors weren’t carrying any genes. Until now, AAV transporters have been thought not to provoke much of an immune response.

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