A variant in the gene for the osteopontin protein has the potential to help predict disease course in Duchenne MD

posted on January 11, 2011 - 2:58pm
A team of scientists working in the United States and Italy has uncovered a variant in the gene for a protein called osteopontin that appears to reliably indicate disease severity in most (but likely not all) cases of Duchenne muscular dystrophy (DMD). The variant is apparently a genetic modifier of DMD, a disease in which the underlying cause is a mutation in the gene for the dystrophin protein...
posted on October 1, 2009 - 10:11am
QUEST Vol. 16, No. 4
The following story includes items about: Becker muscular dystrophy, centronuclear myopathy, type 1A Charcot-Marie-Tooth disease, congenital muscular dystrophy, Duchenne muscular dystrophy, limb-girdle muscular dystrophy, Miyoshi myopathy (distal muscular dystrophy), type 1 myotonic muscular dystrophy, myotubular myopathy, nemaline myopathy, and spinal muscular atrophy

Blocking a protein associated with inflammation and scarring helped mice with a DMD-like disease

posted on May 22, 2009 - 4:23pm
A protein called osteopontin has been implicated as a cause of some of the detrimental inflammation and scarring ("fibrosis") of muscle tissue that takes place in Duchenne muscular dystrophy (DMD). Eliminating osteopontin was beneficial to mice with a DMD-like disease, and the researchers concluded that reducing osteopontin should be investigated as a possible therapy for DMD.