neuromuscular junction

How MDA-supported research to counteract a complement protein and rev up regulatory T cells may improve MG treatment

posted on April 1, 2014 - 9:27am
"I’m on CellCept, prednisone, Mestinon and IVIG every three weeks," says 38-year-old Rachel Pegram. "Prednisone, which I have taken for more than 22 years now, has very rough side effects. It has caused weight gain, diabetes and glaucoma. I cannot say I have ever gone into remission without drugs, but I believe I have been in a drug-induced remission. I have spent a lot of time in hospitals for...

Jacobus Pharmaceutical has opened its original, 30-person, invitation-only trial of 3,4-diaminopyridine for Lambert-Eaton myasthenic syndrome (LEMS) to additional participants who meet study criteria

posted on October 1, 2013 - 5:00am
Update (April 14, 2014): This phase 2 trial of 3,4-diaminopyridine is now closed to new participants. However, the drug remains available on a "compassionate use" -- also called "expanded access" -- basis to qualified patients with LEMS and related disorders of the neuromuscular junction. See Treatment Use of 3,4-Diaminopyridine; or enter NCT01765140 in the search box at
posted on November 1, 2008 - 11:09am
QUEST Vol. 15, No. 6
Story includes research items about: limb-girdle and Duchenne muscular dystrophies, myasthenia gravis, mitochondrial myopathy, Friedreich's ataxia, spinal muscular atrophy