myoblasts

posted on January 1, 2012 - 1:42pm
Stem cells have been much in the news lately, including for neuromuscular diseases. One extremely promising approach has been to create stem cells from the adult (differentiated) cells of humans or animals, and then reprogram them back to a stemlike state, after which they can be redifferentiated into a desired cell type, such as muscle or nerve cells. Stem cells made from differentiated cells...

MDA-supported scientists in Ottawa have found that controlled damage to DNA is required before immature muscle cells can mature into muscle fibers.

posted on February 23, 2010 - 9:48am
Remodeling a building usually requires some degree of dismantling before new construction can begin. That principle, it now seems, also may apply to the remodeling of the body's cells.  Scientists at Ottawa Hospital Research Institute and the University of Ottawa have found recently that it applies to muscle cells, which can only develop from a stemlike state into mature muscle fibers after...

The WNT7a protein increases proliferation of muscle repair cells, a finding that could have implications for MD treatment

posted on June 15, 2009 - 10:12am
In experiments in mice, Michael Rudnicki, an MDA grantee at the Sprott Center for Stem Cell Research at Ottawa Hospital Research Institute (OHRI), and colleagues, found the WNT7a protein stimulates muscle repair by causing proliferation (an increase in number) of "satellite stem cells." They say the protein probably operates similarly in humans. The findings were published June 5, 2009, in the...