Treatment with the protein prolactin improved motor function and enhanced survival time in mice with a disease resembling severe SMA
The administration of a protein called prolactin has been shown to slow weight loss, improve motor function and increase life span by approximately 70 percent in mice with a disease resembling a severe form of spinal muscular atrophy (SMA).
Prolactin is a hormone whose primary function is to promote milk production in women who are breastfeeding.
Real progress is being made in supplying functional dystrophin genes to treat Duchenne muscular dystrophy (DMD), a disease in which mutated dystrophin genes keep this critical protein from being produced in muscle fibers.
Team IDs Consequences of FSH MD Mutation
First mouse model could be used to test therapies
In 1984, two years before mutations in the X-chromosome gene for the muscle protein now known as dystrophin were identified as the cause of Duchenne MD, researchers at the University of California at Berkeley and an agricultural center in Scotland announced they’d found an X-linked muscular dystrophy in mice.
(Doctors had long known that DMD was a genetic disease and that, because of its...