MBNL1

Small molecules that induce or reverse effects of the type 1 myotonic dystrophy mutation in cells in the lab are likely to speed research

posted on July 9, 2013 - 11:01am
Matthew Disney is a current and former MDA grantee at the Scripps Research Institute in Jupiter, Fla. Disney's current MDA grant is focused on targeting toxic RNA in type 2 myotonic dystrophy (MMD2, or DM2).
posted on July 1, 2012 - 3:00pm
QUEST Vol. 19, No. 3
The complex and multifaceted disease known as myotonic muscular dystrophy (MMD) — also known as dystrophia myotonia (DM) — was the subject of an In Focus report in the April-June 2012 Quest. Here, we delve into experimental strategies that may markedly improve the outlook for people with this disorder.

Loss of a protein known as MBNL2 may be responsible for the weakness and muscle atrophy seen in type 1 myotonic dystrophy.

posted on February 2, 2010 - 1:36pm
Scientists at several U.S. institutions have added yet another piece of the puzzle of type 1 myotonic dystrophy (MMD1, also called DM1).
posted on April 1, 2009 - 12:26pm
QUEST Vol. 16, No. 2
Story includes research items about: Charcot-Marie-Tooth disease, congenital muscular dystrophy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy (EDMD), type 1 myotonic muscular dystrophy, and spinal muscular atrophy - including, type 3 SMA and spinal-bulbar muscular atrophy (SBMA, Kennedy disease).