Mani Mahadevan

posted on March 1, 2008 - 10:37pm
Myotonic dystrophy (MMD), a complex disease that results from an expanded and repeated section of DNA on either chromosome 19 (MMD1) or chromosome 3 (MMD2), has long posed a challenge to researchers because of its effects on multiple body systems, its varying degrees of severity and its complex molecular origins.

Can toxic genes be blocked to treat disease?

posted on January 1, 2007 - 3:02pm
QUEST Vol. 14, No. 1
Since the 1990s, gene therapy - the insertion of functional genes to compensate for nonfunctional ones - has been the goal of researchers working in several muscular dystrophies, spinal muscular atrophy, Friedreich's ataxia, metabolic muscle diseases and myotubular myopathy.