Researchers have identified a molecular switch that appears to lead to harmful gene activation in facioscapulohumeral MD

posted on May 7, 2012 - 1:00am
Researchers in Italy and Japan, supported in part by MDA, have identified what they believe is a molecular "switch" that may be inappropriately activating several genes in facioscapulohumeral muscular dystrophy (FSHD).

An 11½-minute interview with researcher Stephen Tapscott explores recent findings about the molecular basis of facioscapulohumeral MD

posted on February 2, 2012 - 4:55pm
A protein called DUX4, inappropriately produced ("expressed") in skeletal muscle fibers, is emerging as a major factor in facioscapulohumeral muscular dystrophy (FSHD). In FSHD-affected muscles, full-length DUX4 protein disrupts numerous biochemical pathways that normally would help muscle cells survive, mature and develop specialized roles.

A protein called DUX4, normally active only during early development, probably damages FSHD-affected muscle fibers and could become a target for drug development

posted on October 29, 2010 - 11:00am
Little by little, the molecular underpinnings of facioscapulohumeral muscular dystrophy (FSHD) are yielding to scientific investigations. The latest revelations about a protein known as DUX4, announced in October, could bring a treatment for FSHD closer to the clinic. About recent FSHD research

Activist and entrepeneur receives top achievement honor

posted on October 1, 2010 - 2:15pm
QUEST Vol. 17, No. 4
A retired gas industry executive, disability rights activist, green energy entrepreneur and father of a 3-year-old boy has been named the recipient of MDA’s Robert Ross National Personal Achievement Award (PAA) for 2011. Thomas Arrington III, 48, from Chesapeake, Va., was chosen for the honor from among scores of recipients of statewide PAA awards, based on his personal success and achievements,...

Coping with facial weakness in FSHD

posted on June 1, 1997 - 3:34pm
Songs tell us we're never fully dressed without a smile and exhort us to pack up our troubles in our old kit bags and — smile, smile, smile. Smiling mouths tell us to buy everything from toothpaste and shampoo to diamonds and automobiles, and stylized "smiley faces" peer at us from posters and stickers. There's more space in the brain devoted to muscle control of the face than to any other...