DUX4 gene

MDA-supported researchers have developed a research mouse with the same molecular abnormalities that underlie human types 1 and 2 facioscapulohumeral muscular dystrophy

posted on April 4, 2013 - 2:00pm
A newly developed research mouse that has the same combination of genetic alterations that causes human facioscapulohumeral muscular dystrophy (FSHD) is expected to change the way research in this disease is conducted, possibly speeding the development of therapies. Unlike humans, mice normally do not have a DNA structure called a D4Z4 repeat array that, when altered, causes FSHD. Therefore, FSHD...

A protein called DUX4, normally active only during early development, probably damages FSHD-affected muscle fibers and could become a target for drug development

posted on October 29, 2010 - 11:00am
Little by little, the molecular underpinnings of facioscapulohumeral muscular dystrophy (FSHD) are yielding to scientific investigations. The latest revelations about a protein known as DUX4, announced in October, could bring a treatment for FSHD closer to the clinic. About recent FSHD research
posted on December 31, 2009 - 1:17am
QUEST Vol. 17, No. 1
Featured in this issue: Duchenne and Becker MD ** Facioscapulohumeral MD ** Friedreich's ataxia ** Limb-Girdle muscular dystrophy ** Myotonic dystrophy ** Spinal muscular atrophy

New findings show abnormally activated parts of a gene called DUX4 may underlie FSH dystrophy

posted on August 27, 2009 - 11:45am
An MDA-supported team of scientists in the United States and the Netherlands has uncovered new leads about the origins of facioscapulohumeral muscular dystrophy (FSHD), a disease whose biochemical underpinnings have proved elusive to scientists despite years of investigation.