Are myelin and axons 'talking' to each other — and what are they saying?
MDA-supported research in Charcot-Marie-Tooth disease is focused on figuring out what goes wrong at the molecular level in CMT-affected axons or the myelin sheaths that surround them, rather than on attempting to fix the problem directly or preserving nerve function in spite of it. A central theme emerging from the last decade of research is that myelin and axons require constant signals from...
A useful but unwieldy CMT classification system helps make sense of the many subtypes of the disease
As recently as the early 1990s, many experts hoped that understanding just a few genes that influenced the development or maintenance of myelin or axons would explain all of Charcot-Marie-Tooth disease.
It didn’t turn out to be that simple, however. Today, there are dozens of genes recognized that, when flawed, can cause CMT.
A nonprofit led by a teacher and minister with limb-girdle MD again is offering postgraduate scholarships and small quality-of-life grants
(Update 9/14/11: The 2011 scholarship winners have been selected. To view a list of winners visit www.deshae.org/cmms/awards/2011/scholars.pdf. Applications for quality of life grants continue to be accepted and are awarded on an ongoing basis.)
Dr. Phillip Chance, 41, associate professor of neurology and pediatrics at the University of Pennsylvania, and Dr. Jim Lupski, 37, associate professor at Baylor College of Medicine's Institute for Molecular Genetics, have a lot in common as major players in MDA's genetics research in Charcot-Marie-Tooth disease.