autophagy

Eliminating a protein enhanced cellular cleanup, saved nerve cells and prolonged survival in female ALS mice

posted on September 29, 2009 - 1:30pm
New research supports strategies that augment a natural process in the nervous system called autophagy – a cellular cleanup and garbage-disposal system — as a possible therapeutic avenue in amyotrophic lateral sclerosis (ALS). Autophagy (literally "self-eating") is activated when large amounts of debris and abnormal cellular components require destruction.
posted on April 1, 2009 - 12:26pm
QUEST Vol. 16, No. 2
Story includes research items about: Charcot-Marie-Tooth disease, congenital muscular dystrophy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy (EDMD), type 1 myotonic muscular dystrophy, and spinal muscular atrophy - including, type 3 SMA and spinal-bulbar muscular atrophy (SBMA, Kennedy disease).

Nerve-cell defense mechanism may hold key to SBMA treatment

posted on January 3, 2009 - 3:13pm
A defense mechanism called “autophagy” that neurons (nerve cells) use to protect themselves from dangerous misfolded proteins may hold the key to developing treatments for spinal-bulbar muscular atrophy (SBMA, or Kennedy disease) and perhaps similar neurodegenerative diseases, new research shows.