Allison Ebert; Christian Lorson; SMA-affected motor neurons; stemcells

SMA cell 'reprogramming' may significantly aid search for effective drugs

posted on January 28, 2009 - 2:01pm
In a development that could lead to better screening of drugs for spinal muscular atrophy (SMA), skin cells from a child with SMA1 have been "reprogrammed" back to a stemlike state and then coaxed to develop into SMA-affected motor neurons, the nerve cells that normally control muscle movement but malfunction and die in this disease.

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