CMT-1B (MPZ)

Stanford University is collecting samples of blood, muscle and other tissues from people with neuromuscular disorders for use in research

posted on January 7, 2015 - 12:06pm
Ever wondered how someone with a neuromuscular disorder in his or her family might contribute to research efforts in this field?

MDA-supported researchers report that mice with a disorder resembling type 1B Charcot-Marie-Tooth disease benefited from treatment with curcumin, a component of the spice turmeric

posted on January 21, 2013 - 5:00am
Mice with a disorder resembling the type 1B form of Charcot-Marie-Tooth disease (CMT) benefited from treatment with either of two forms of oral curcumin, a component of the spice turmeric, according to researchers supported in part by MDA.

A multinational study supported by MDA and NINDS will study correlations between mutations and symptoms in four subtypes of Charcot-Marie-Tooth disease

posted on November 10, 2011 - 6:00am
A large-scale study, supported in part by MDA, seeks to determine the natural history (general disease course) of four subtypes of Charcot-Marie-Tooth disease (CMT), with particular emphasis on correlations between genetic mutations and symptoms. The four subtypes are CMT1B, CMT2A, CMT4A and CMT4C.

Research items about Friedreich's ataxia, myasthenia gravis, mitochondrial myopathies, type 1 myotonic dystrophy, gene therapy and gene modification

posted on July 7, 2011 - 10:28am
Edison drugs target FA, mitochondrial diseases

Are myelin and axons 'talking' to each other — and what are they saying?

posted on July 1, 2011 - 3:52pm
QUEST Vol. 18, No. 3
MDA-supported research in Charcot-Marie-Tooth disease is focused on figuring out what goes wrong at the molecular level in CMT-affected axons or the myelin sheaths that surround them, rather than on attempting to fix the problem directly or preserving nerve function in spite of it. A central theme emerging from the last decade of research is that myelin and axons require constant signals from...

Individuals with CMT are encouraged to participate in a new international database

posted on July 1, 2011 - 3:40pm
QUEST Vol. 18, No. 3
The field of Charcot-Marie-Tooth disease (CMT) research is expanding, and people with the disease can help move it forward. Discovery of the complicated genetics underlying CMT has made it clear that more studies are needed to correlate the progression, symptoms and outward manifestations of the disease with its specific genetic type.

Streamlined diagnostic procedures, better data collection, a new clinical trials network and new laboratory research are the foundations of MDA's CMT program

posted on June 30, 2011 - 1:27pm
QUEST Vol. 18, No. 3
It begins with weakness in the muscles of the lower legs and feet, causing frequent tripping and ankle injuries. Feet are often so high-arched that comfortable shoes can’t be found. Hands also can be affected, making it difficult to hold a pencil, type on a computer or play a musical instrument. Loss of sensation in the lower legs, feet, hands and forearms often occurs. Although not as...

Curcumin (which makes the spice turmeric yellow) benefited mice with a disease resembling type 1B Charcot-Marie-Tooth

posted on April 21, 2010 - 4:25pm
Mice with a genetic mutation in the myelin protein zero (MPZ) gene, which develop a disease resembling human type 1B Charcot-Marie-Tooth disease (CMT1B), benefited from treatment with curcumin and curcumin derivatives, researchers announced April 15, at the 2010 meeting of the American Academy of Neurology (AAN), held in Toronto.