Sporadic ALS

Stanford University is collecting samples of blood, muscle and other tissues from people with neuromuscular disorders for use in research

posted on January 7, 2015 - 12:06pm
Ever wondered how someone with a neuromuscular disorder in his or her family might contribute to research efforts in this field?

Top researchers are discussing notable developments in neuroscience, including research in many neuromuscular diseases, at the annual American Academy of Neurology meeting April 21-28

posted on April 24, 2012 - 4:00am
Top scientists and clinicians from around the world are discussing the latest research in neuroscience, and the care of individuals with nerve and muscle diseases, at the 2012 annual meeting of the American Academy of Neurology in New Orleans, April 21-28.

Scientists know more about familial ALS (FALS) than sporadic ALS; FALS research may have application for both forms of the disease, however. 

posted on April 2, 2010 - 2:21pm
The state of research in the familial (inherited) form of ALS was the focus of a special one-hour Webinar presented by the ALS Therapy Development Institute (ALS TDI) on March 25, with reports by CEO & Chief Scientific Officer Steve Perrin.

After a two-year review, the FDA approves reopening a clinical trial of the experimental compound arimoclomol.

posted on December 8, 2009 - 5:45pm
A clinical trial of an experimental drug for ALS -- halted almost two years ago due to safety concerns –- has been given the green light to continue with a revised protocol, says CytRx Corp. of Los Angeles, the drug’s manufacturer. The U.S. Food and Drug Administration placed a hold on the phase 2b trial of arimoclomol in January 2008, saying it wanted to see more toxicity data from previously...

A new type of ALS research mouse, with a mutation in the TDP43 gene, has been developed

posted on October 8, 2009 - 9:00pm
Mice carrying a mutation in the gene for the TDP43 protein that's known to cause amyotrophic lateral sclerosis (ALS) in humans have been developed by MDA-supported scientists at Washington University School of Medicine in St. Louis. The mice may provide an important new research tool in this deadly disease.

Eliminating a protein enhanced cellular cleanup, saved nerve cells and prolonged survival in female ALS mice

posted on September 29, 2009 - 1:30pm
New research supports strategies that augment a natural process in the nervous system called autophagy – a cellular cleanup and garbage-disposal system — as a possible therapeutic avenue in amyotrophic lateral sclerosis (ALS). Autophagy (literally "self-eating") is activated when large amounts of debris and abnormal cellular components require destruction.

A multinational team found three new DNA variations that may increase the risk of developing ALS

posted on September 22, 2009 - 8:53am
A large, multinational study to identify genetic risk factors associated with amyotrophic lateral sclerosis (ALS) has found two DNA sequences on chromosomes 9 and one on chromosome 19 that are significantly different in people with and without the disease and may contribute to its development.

An analysis shows no single PON gene variant increases ALS risk, but doesn't rule out ALS-PON connections

posted on July 13, 2009 - 8:31am
  A new meta-analysis combining data from 11 studies has found no connection between variations in genes for paraoxonase (PON) enzymes and an increased risk of developing amyotrophic lateral sclerosis (ALS).